Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach

被引：35

作者：

Kim, Chang-Gon ^{[1
]}

Sang, Yun-Beom ^{[2
]}

Lee, Ji-Hyun ^{[1
]}

Chon, Hong-Jae ^{[2
]}

机构：

[1] Yonsei Univ, Yonsei Canc Ctr, Dept Internal Med, Div Med Oncol,Coll Med, Seoul 03722, South Korea

[2] CHA Univ, CHA Bundang Med Ctr, Med Oncol, Sch Med, Seongnam 13497, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 15期

基金：

新加坡国家研究基金会;

关键词：

therapeutic cancer vaccine; combination immunotherapy; immune checkpoint inhibitor; tumor microenvironment; T-CELL RESPONSES; PHASE-I TRIAL; DNA VACCINE; DENDRITIC CELLS; TALIMOGENE LAHERPAREPVEC; TUMOR MICROENVIRONMENT; PD-1/PD-L1; BLOCKADE; NEOANTIGEN VACCINE; SYNTHETIC DNA; PD-1;

D O I：

10.3390/ijms22158035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Therapeutic cancer vaccines have become increasingly qualified for use in personalized cancer immunotherapy. A deeper understanding of tumor immunology and novel antigen delivery technologies has assisted in optimizing vaccine design. Therapeutic cancer vaccines aim to establish long-lasting immunological memory against tumor cells, thereby leading to effective tumor regression and minimizing non-specific or adverse events. However, due to several resistance mechanisms, significant challenges remain to be solved in order to achieve these goals. In this review, we describe our current understanding with respect to the use of the antigen repertoire in vaccine platform development. We also summarize various intrinsic and extrinsic resistance mechanisms behind the failure of cancer vaccine development in the past. Finally, we suggest a strategy that combines immune checkpoint inhibitors to enhance the efficacy of cancer vaccines.

引用

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