An Overview of Genome-Wide Association Studies in Alzheimer's Disease

被引：67
|
作者：
Shen, Luxi [1 ]
Jia, Jianping [1 ,2 ,3 ,4 ]
机构：
[1] Capital Med Univ, Xuan Wu Hosp, Dept Neurol, Beijing 100053, Peoples R China
[2] Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China
[3] Beijing Key Lab Geriatr Cognit Disorders, Beijing 100053, Peoples R China
[4] Minist Educ Peoples Republ China, Neurodegenerat Lab, Beijing 100053, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2016年 / 32卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Association analysis; Alzheimer's disease susceptibility genes; Apolipoprotein E; Common variant; SUSCEPTIBILITY LOCI; MISSING HERITABILITY; IDENTIFIES VARIANTS; MISSENSE MUTATIONS; GENETIC-VARIATION; APOLIPOPROTEIN-E; COMMON VARIANTS; ONSET; RISK; APOE;
D O I：
10.1007/s12264-016-0011-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.
引用
收藏
页码：183 / 190
页数：8
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