DNA-binding behavior of ruthenium(II) complexes containing both group 15 donors and 2,2′:6′,2"-terpyridine

被引：96

作者：

Sharma, S ^{[1
]}

Singh, SK ^{[1
]}

Chandra, M ^{[1
]}

Pandey, DS ^{[1
]}

机构：

[1] Awadhesh Pratap Singh Univ, Dept Chem, Rewa 486003, Madhya Pradesh, India

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 02期

关键词：

ruthenium(II) terpyridine complexes; DNA interactions; DNA binding constant; weak interactions; helical;

D O I：

10.1016/j.jinorgbio.2004.10.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetrafluoroborate salts of cationic ruthenium complexes [Ru(kappa(3)-tpy)(EPh3)(2)Cl](+) (tpy = 2,2':6',2"-terpyridine; E = P, 1 or As, 2) containing both the group 15 donor ligands and tpy and their representative substitution products are reported. Weak interaction {C-(HX)-X-... (X = Cl, F and pi) and pi-pi interactions studies revealed the presence of a double helical motif in complex 1, while the complex 2 assumes a single helical motif. Intercalative mode of interaction of the complexes 1 and 2 with calf thymus DNA (ctDNA) has been supported by absorption titration studies. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：458 / 466

页数：9

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