Cell death or synaptic loss in Alzheimer disease

被引：154

作者：

Terry, RD ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2000年 / 59卷 / 12期

关键词：

Alzheimer; cognition; synapses; neurons;

D O I：

10.1093/jnen/59.12.1118

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It is an erroneous but common assumption that loss of neuronal perikarya causes the cognitive change in Alzheimer disease. Neither are senile plaques nor neurofibrillary tangles primarily to blame. In fact, it is the loss of synaptic contact that leads directly to the personal devastation. The death of neocortical synapses in the neuropil between plaques is probably the factor that activates the microglia.

引用

页码：1118 / 1119

页数：2

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