Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

被引：169

作者：

Cho, Aesop ^{[1
]}

Saunders, Oliver L. ^{[1
]}

Butler, Thomas ^{[1
]}

Zhang, Lijun ^{[1
]}

Xu, Jie ^{[1
]}

Vela, Jennifer E. ^{[1
]}

Feng, Joy Y. ^{[1
]}

Ray, Adrian S. ^{[1
]}

Kim, Choung U. ^{[1
]}

机构：

[1] Gilead Sci Inc, Foster City, CA 94044 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期

关键词：

C-nucleoside; Antiviral; Polymerase inhibitor; ANALOG;

D O I：

10.1016/j.bmcl.2012.02.105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1 '-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R = CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate. (C) 2012 Elsevier Ltd. All rights reserved.

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页码：2705 / 2707

页数：3

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