Physicochemical properties and thermal stability of quercetin hydrates in the solid state

被引：69

作者：

Borghetti, G. S. ^{[1
]}

Carini, J. P. ^{[1
]}

Honorato, S. B. ^{[2
]}

Ayala, A. P. ^{[2
]}

Moreira, J. C. F. ^{[3
]}

Bassani, V. L. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Fac Farm, Programa Posgrad Ciencias Farmaceut, BR-90610000 Porto Alegre, RS, Brazil

[2] Univ Fed Ceara, Dept Fis, BR-60455970 Fortaleza, Ceara, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil

来源：

THERMOCHIMICA ACTA | 2012年 / 539卷

关键词：

Hydrates; Physicochemical properties; Quercetin; Solid state; Thermal stability; POLYMORPHISM; COMPLEX; ANTIOXIDANT; DIHYDRATE; SPECTRA; DRUGS; FORMS; RAMAN;

D O I：

10.1016/j.tca.2012.04.015

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

In the present work three samples of quercetin raw materials (QCTa, QCTb and QCTc), purchased from different Brazilian suppliers, were characterized employing scanning electron microscopy, Raman spectroscopy, simultaneous thermogravimetry and infrared spectroscopy, differential scanning calorimetry, and variable temperature-powder X-ray diffraction, in order to know their physicochemical properties, specially the thermal stability in solid state. The results demonstrated that the raw materials of quercetin analyzed present distinct crystalline structures, ascribed to the different degree of hydration of their crystal lattice. The thermal stability of these quercetin raw materials in the solid state was highly dependent on their degree of hydration, where QCTa (quercetin dihydrate) was thermodynamically more stable than the other two samples. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：109 / 114

页数：6

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