Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats

被引：15

作者：

Akgul, Turgay ^{[1
]}

Ayyildiz, Ali ^{[1
]}

Nuhoglu, Baris ^{[1
]}

Karaguzel, Ersagun ^{[1
]}

Ogus, Elmas ^{[2
]}

Yagmurdur, Hatice ^{[3
]}

Ustun, Huseyin ^{[4
]}

Germiyanoglu, Cankon ^{[1
]}

机构：

[1] Minist Hlth Ankara Training & Res Hosp, Urol Clin 2, TR-06500 Ankara, Turkey

[2] Minist Hlth Ankara Training & Res Hosp, Dept Biochem, TR-06500 Ankara, Turkey

[3] Minist Hlth Ankara Training & Res Hosp, Dept Anesthesiol, TR-06500 Ankara, Turkey

[4] Minist Hlth Ankara Training & Res Hosp, Dept Pathol, TR-06500 Ankara, Turkey

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2008年 / 40卷 / 03期

关键词：

ginkgo biloba; ischemia reperfusion; nitric oxide; testicular torsion; testis;

D O I：

10.1007/s11255-007-9296-5

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Materials and methods Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T/D, group 3 received only gingko biloba (50 mg/day) for a month and group 4 was defined as sham group. After 1 month the testes were removed. Results Mean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P < 0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. Conclusions Malondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.

引用

页码：685 / 690

页数：6

共 30 条

[1] The effects of N-acetylcysteine on antioxidant enzyme activities in experimental testicular torsion
Çay, A
Alver, A
Kuçuk, M
Isik, O
Eminagaoglu, MS
Karahan, SC
Deger, O
[J]. JOURNAL OF SURGICAL RESEARCH, 2006, 131 (02) : 199 - 203
[2] Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway
Chen, X
Salwinski, S
Lee, TJF
[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1997, 24 (12) : 958 - 959
[3] CLOSTRE F, 1999, ANN PHARM FR, V57, P18
[4] Adult testicular torsion
Cummings, JM
Boullier, JA
Sekhon, D
Bose, K
[J]. JOURNAL OF UROLOGY, 2002, 167 (05) : 2109 - 2110
[5] Eckert A, 2003, PHARMACOPSYCHIATRY, V36, pS15
[6] Filho Danilo Wilhelm, 2004, Mol Aspects Med, V25, P199, DOI 10.1016/j.mam.2004.02.020
[7] ANALYSIS OF NITRATE, NITRITE, AND [N-15]-LABELED NITRATE IN BIOLOGICAL-FLUIDS
GREEN, LC
WAGNER, DA
GLOGOWSKI, J
SKIPPER, PL
WISHNOK, JS
TANNENBAUM, SR
[J]. ANALYTICAL BIOCHEMISTRY, 1982, 126 (01) : 131 - 138
[8] The protective role of erdosteine on testicular tissue after testicular torsion and detorsion
Koc, A
Narci, A
Duru, M
Gergerlioglu, HS
Akaydin, Y
Sogut, S
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2005, 280 (1-2) : 193 - 199
[9] THE EMERGING MULTIFACETED ROLES OF NITRIC-OXIDE
KUO, PC
SCHROEDER, RA
[J]. ANNALS OF SURGERY, 1995, 221 (03) : 220 - 235
[10] Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat
Mogilner, JG
Lurie, M
Coran, AG
Nativ, O
Shiloni, E
Sukhotnik, I
[J]. PEDIATRIC SURGERY INTERNATIONAL, 2006, 22 (01) : 99 - 105

← 1 2 3 →