A Ce(III)-catalyzed expeditious multicomponent stereoselective synthesis of 3-mercapto-2(1H)-pyridinones

被引：24

作者：

Yadav, Lal Dhar S. ^{[1
]}

Kapoor, Ritu ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Green Synth Lab, Allahabad 211002, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 33期

关键词：

multicomponent reaction; Lewis acid; chalcones; 1,3-oxathiolan-5-one; 3-mercapto-2(1H)-pyridinones; stereoselective synthesis;

D O I：

10.1016/j.tetlet.2008.06.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Ce(III)-catalyzed, convenient, expeditious, and chastereoselective synthesis of 3-mercapto-2(IH)-pyridinones via one-pot, [3+2+1] three-component coupling reactions of chalcones, 2-methyl-2-phenyl-1,3 -oxathiolan-5-one, and amines is reported. The synthesis involves sequential Michael addition, condensation, and ring transformation. Ambient temperature, operational simplicity, use of an environmentally clean catalyst, high yields, and diastereoselectivity are the key features of the present synthetic Protocol. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4840 / 4844

页数：5

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