Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide

被引：19

作者：

Baek, Seung-Woon ^{[1
,2
,3
]}

Kim, Da-Seul ^{[1
,4
]}

Song, Duck Hyun ^{[1
]}

Kim, Han Byul ^{[5
]}

Lee, Semi ^{[1
]}

Kim, Jun Hyuk ^{[1
]}

Lee, Jun-Kyu ^{[1
]}

Hong, Young Joon ^{[6
]}

Park, Chun Gwon ^{[2
,3
]}

Han, Dong Keun ^{[1
]}

机构：

[1] CHA Univ, Dept Biomed Sci, 335 Pangyo Ro, Seongnam Si 13488, Gyeonggi, South Korea

[2] Sungkyunkwan Univ SKKU, SKKU Inst Convergence, Dept Biomed Engn, 2066 Seobu Ro, Suwon 16419, Gyeonggi, South Korea

[3] Sungkyunkwan Univ, SKKU Inst Convergence, Dept Intelligent Precis Healthcare Convergence, 2066 Seobu Ro, Suwon 16419, Gyeonggi, South Korea

[4] Chung Ang Univ, Sch Integrat Engn, 84 Heukseok Ro, Seoul 06974, South Korea

[5] Natl Univ Hosp, Cardiovasc Convergence Res Ctr Chonnam, Korea Minist Hlth & Welf, 42 Jebong Ro, Gwangju 61469, South Korea

[6] Natl Univ Hosp, Cardiovasc Convergence Res Ctr, Div Cardiol Chonnam, Korea Minist Hlth & Welf, 42 Jebong Ro, Gwangju 61469, South Korea

来源：

BIOMATERIALS RESEARCH | 2022年 / 26卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Cardiovascular disease; Biodegradable vascular scaffold; Everolimus; Magnesium hydroxide; Restenosis; Re-endothelialization; Inflammation; MAMMALIAN TARGET; ACTIVATION; STENTS; PLLA;

D O I：

10.1186/s40824-022-00334-x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

BackgroundCoronary artery disease is a cardiovascular disease with a high mortality and mortality rate in modern society. Vascular stent insertion to restore blood flow is essential to treat this disease. A fully biodegradable vascular scaffold (BVS) is a vascular poly (L-lactic acid) (PLLA) stent that is receiving growing interest as this is biodegradable in the body and does not require secondary removal surgery. However, acidic byproducts composed of PLLA produced during the biodegradation of the BVS can induce an inflammatory response. Magnesium hydroxide, a basic inorganic particle, neutralizes the acidic byproducts of PLLA. MethodsIn this study, we investigated using a BVS coated with everolimus and surface-modified magnesium hydroxide that suppresses smooth muscle cell proliferation and protects endothelial cells, respectively. The various characteristics of the functional stent were evaluated using in vitro and in vivo analyses. ResultsThe BVS was successfully prepared with evenly coated everolimus and surface-modified magnesium hydroxide. A neutral pH value was maintained by magnesium hydroxide during degradation, and everolimus was released for one month. The coated BVS effectively inhibited protein adsorption and platelet adhesion, demonstrating excellent blood compatibility. In vitro analysis showed that BVS protects endothelial cells with magnesium hydroxide and selectively inhibits smooth muscle cell proliferation via everolimus treatment. The functional BVS was inserted into porcine coronary arteries for 28 days, and the results demonstrated that the restenosis and inflammation greatly decreased and re-endothelialization was enhanced as compared to others. ConclusionsThis study provides new insights into the design of drug-incorporated BVS stent for coronary artery disease.

引用

页数：17

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