Efficient Synthesis and Characterization of Monoprotected Symmetrical Poly(Ethylene Glycol) Diamine

被引：4

作者：

Jeong, Hyeri ^{[1
]}

Youn, Dayoung ^{[1
]}

Nam, Jihye ^{[1
]}

Kim, Jaehi ^{[2
]}

Lee, Yoon-Sik ^{[2
]}

Shin, Dong-Sik ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Dept Chem & Biol Engn, Seoul 04310, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 08826, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2018年 / 39卷 / 01期

关键词：

Monofunctionalization; Solid-phase synthesis; 2-Chlorotrityl chloride resin; Poly(ethylene glycol); Fmoc group; 2-CHLOROTRITYL RESIN; PEPTIDE; DELIVERY; FMOC; PEG;

D O I：

10.1002/bkcs.11335

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solid-phase synthesis of monoprotected poly(ethylene glycol) (PEG) diamine is demonstrated. 2-Chlorotrityl chloride (2-CTC) resin was used as a solid support for inducing monofunctionalization using excess PEG diamine. Fmoc-monoprotected PEG was prepared from 2-CTC resin and fully characterized by high-performance liquid chromatography and electrospray ionization mass spectrometry. We envision that this strategy will provide an efficient method of preparing various kinds of heterobifunctional PEG molecules without a need for further purification steps.

引用

页码：29 / 32

页数：4

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