Molecular Mechanism of Hippo-YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration

被引:61
作者
Chen, Xiaoqing [1 ,2 ,3 ,4 ]
Li, Yilang [1 ,2 ,3 ,4 ]
Luo, Jiandong [1 ,2 ,3 ,4 ]
Hou, Ning [1 ,2 ,3 ,4 ]
机构
[1] Guangzhou Med Univ, Key Lab Mol Target & Clin Pharmacol, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Guangzhou Key Lab Cardiovasc Dis, Guangzhou Inst Cardiovasc Dis, Guangzhou, Guangdong, Peoples R China
[4] Guangzhou Med Univ, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
来源
FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷
基金
中国国家自然科学基金;
关键词
YAP1; TAZ; Hippo pathway; post-translational modification; heart development; cardiac disease; regeneration; HIPPO PATHWAY; CARDIOMYOCYTE PROLIFERATION; ISCHEMIA/REPERFUSION INJURY; CARDIAC-HYPERTROPHY; PRESSURE-OVERLOAD; YAP ACTIVATION; SIZE-CONTROL; YAP/TAZ; CELLS; SURVIVAL;
D O I
10.3389/fphys.2020.00389
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The Hippo-YAP1/TAZ pathway is a highly conserved central mechanism that controls organ size through the regulation of cell proliferation and other physical attributes of cells. The transcriptional factors Yes-associated protein 1 (YAP1) and PDZ-binding motif (TAZ) act as downstream effectors of the Hippo pathway, and their subcellular location and transcriptional activities are affected by multiple post-translational modifications (PTMs). Studies have conclusively demonstrated a pivotal role of the Hippo-YAP1/TAZ pathway in cardiac development, disease, and regeneration. Targeted therapeutics for the YAP1/TAZ could be an effective treatment option for cardiac regeneration and disease. This review article provides an overview of the Hippo-YAP1/TAZ pathway and the increasing impact of PTMs in fine-tuning YAP1/TAZ activation; in addition, we discuss the potential contributions of the Hippo-YAP1/TAZ pathway in cardiac development, disease, and regeneration.
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页数:17
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