Experimental Therapeutic Trial Design for Pediatric Brain Tumors

被引：1

作者：

Bornhorst, Miriam ^{[1
,2
]}

Hwang, Eugene I. ^{[1
,3
,4
]}

机构：

[1] Childrens Natl Med Ctr, Dept Pediat Hematol Oncol, Washington, DC 20010 USA

[2] Brain Tumor Inst, Washington, DC USA

[3] Childrens Natl Med Ctr, Gilbert Family Neurofibromatosis Inst, Ctr Canc & Immunol Res, 111 Michigan Ave NW, Washington, DC 20010 USA

[4] Childrens Natl Med Ctr, Gilbert Family Neurofibromatosis Inst, Ctr Neurosci Res, 111 Michigan Ave NW, Washington, DC 20010 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2016年 / 31卷 / 12期

关键词：

clinical trial; pediatric; targeted therapy; design; treatment; BEVACIZUMAB PLUS IRINOTECAN; MGMT PROMOTER METHYLATION; NATIONAL-CANCER-INSTITUTE; LOW-GRADE GLIOMAS; PHASE-I TRIALS; CLINICAL-TRIALS; MALIGNANT GLIOMAS; SOLID TUMORS; CHILDREN; RECURRENT;

D O I：

10.1177/0883073815604221

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pediatric brain tumors are the leading cause of cancer-related death during childhood. Since the first pediatric brain tumor clinical trials, the field has seen improved outcomes in some, but not all tumor types. In the past few decades, a number of promising new therapeutic agents have emerged, yet only a few of these agents have been incorporated into clinical trials for pediatric brain tumors. In this review, the authors discuss the process of and challenges in pediatric clinical trial design; this will allow for highly efficient and effective clinical trials with appropriate endpoints to ensure rapid and safe investigation of novel therapeutics for children with brain tumors.

引用

页码：1421 / 1432

页数：12

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