Radiation-induced intra- and extra-cranial high-grade myxofibrosarcoma with tumor bleeding

Radiation-induced secondary malignant neoplasms in central nervous system tumor survivors have become a problem of increasing concern over the last 20 years because Of rare but serious and potentially fatal complications. Herein, we report the case of a 28-year-old man who presented with a left fronto-temporal intra- and extra-cranial tumor With intra-tumor bleeding at the site of previous radiotherapy in May 1991. He Underwent craniotomy with gross total removal of the tumor and surrounding hematoma in August 2005. The tumor was it high-grade malignant myxofibrosarcoma (Federation Nationale des Centres de Lutte Contre le Cancer Grade III [out of III]). Radiation-induced malignant rnyxotibrosarcoma with tumor bleeding is an infrequent complication of radiotherapy. Although rare, it Should always be kept in mind with regards to the differential diagnosis of a lesion that develops several years after radiation therapy. Also, follow-up of patients that have undergone radiation therapy should be long-term. (c) 2007 Elsevier Ltd. All rights reserved.