A rapid efficient microwave-assisted synthesis of a 3′,5′-pentathymidine by copper(I)-catalyzed [3+2] cycloaddition

被引：63

作者：

Lucas, Romain ^{[1
]}

Zerrouki, Rachida ^{[1
]}

Granet, Robert ^{[1
]}

Krausz, Pierre ^{[1
]}

Champavier, Yves ^{[2
]}

机构：

[1] Fac Sci & Tech, Lab Chim Substances Nat EA 1069, F-87060 Limoges, France

[2] Univ Limoges, Serv Commun RMN, Fac Pharm, F-87025 Limoges, France

来源：

TETRAHEDRON | 2008年 / 64卷 / 23期

关键词：

pentathymidine; click chemistry; microwave;

D O I：

10.1016/j.tet.2008.04.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 5'-O-tosylthymidine, sequential azidation and Cu-catalyzed [3+2] azide-alkyne 1,3-dipolar cycloaddition led to the formation of a 3',5'-pentathymidine in high yield. The whole process needed only work-up/precipitation steps and was completed within just 18 min, thanks to microwave activation. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5467 / 5471

页数：5

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