Myeloperoxidase: A new biomarker of inflammation in ischemic heart disease and acute coronary syndromes

被引：240

作者：

Loria, Valentina ^{[1
]}

Dato, Ilaria ^{[1
]}

Graziani, Francesca ^{[1
]}

Biasucci, Luigi M. ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy

来源：

MEDIATORS OF INFLAMMATION | 2008年 / 2008卷

关键词：

D O I：

10.1155/2008/135625

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation thatmyeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS). Copyright (C) 2008.

引用

页数：4

共 17 条

[1] Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes [J].

Baldus, S ;

Heeschen, C ;

Meinertz, T ;

Zeiher, AM ;

Eiserich, JP ;

Münzel, T ;

Simoons, ML ;

Hamm, CW .

CIRCULATION, 2003, 108 (12) :1440-1445

[2] Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia [J].

Biasucci, LM ;

DOnofrio, G ;

Liuzzo, G ;

Zini, G ;

Monaco, C ;

Caligiuri, G ;

Tommasi, M ;

Rebuzzi, AG ;

Maseri, A .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 27 (03) :611-616

[3] Prognostic value of myeloperoxidase in patients with chest pain [J].

Brennan, M ;

Penn, MS ;

Van Lente, F ;

Nambi, V ;

Shishehbor, MH ;

Aviles, RJ ;

Goormastic, M ;

Pepoy, ML ;

McErlean, ES ;

Topol, EJ ;

Nissen, SE ;

Hazen, SL .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (17) :1595-1604

[4] Widespread coronary inflammation in unstable angina [J].

Buffon, A ;

Biasucci, LM ;

Liuzzo, G ;

D'Onofrio, G ;

Crea, F ;

Maseri, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (01) :5-12

[5] Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome [J].

Cavusoglu, Erdal ;

Ruwende, Cyril ;

Eng, Calvin ;

Chopra, Vineet ;

Yanamadala, Sunitha ;

Clark, Luther T. ;

Pinsky, David J. ;

Marmur, Jonathan D. .

AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (10) :1364-1368

[6]

Holvoet P, 1998, ACTA CARDIOL, V53, P253

[7] Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction [J].

Khan, Sohail Q. ;

Kelly, Dominic ;

Quinn, Paulene ;

Davies, Joan E. ;

Ng, Leong L. .

HEART, 2007, 93 (07) :826-831

[8]

Li Shi-hong, 2007, Zhonghua Xinxueguanbing Zazhi, V35, P241

[9] Serum Myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals - The EPIC-Norfolk prospective population study [J].

Meuwese, Marijn C. ;

Stroes, Erik S. G. ;

Hazen, Stanley L. ;

van Miert, Joram N. ;

Kuivenhoven, Jan Albert ;

Schaub, Robert G. ;

Wareham, Nicholas J. ;

Luben, Robert ;

Kastelein, John J. P. ;

Khaw, Kay-Tee ;

Boekholdt, S. Matthijs .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (02) :159-165

[10] Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction [J].

Mocatta, Tessa J. ;

Pilbrow, Anna P. ;

Cameron, Vicky A. ;

Senthilmohan, Revathy ;

Frampton, Chris M. ;

Richards, A. Mark ;

Winterbourn, Christine C. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (20) :1993-2000

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