Transition-metal-free, visible-light-induced oxidative cross-coupling for constructing β-acetylamino acrylosulfones from sodium sulfinates and enamides

被引：68

作者：

Sun, Deli ^{[1
]}

Zhang, Ronghua ^{[1
,2
]}

机构：

[1] Tongji Univ, Sch Chem Sci & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China

[2] Tongji Univ, Shanghai Key Lab Chem Assessment & Sustainabil, 1239 Siping Rd, Shanghai 200092, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PHOTOREDOX CATALYSIS; VINYL SULFONES; SULFUR-DIOXIDE; KETO-SULFONES; EOSIN Y; DECARBOXYLATIVE SULFONYLATION; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC HYDROGENATION; DIRECT OXYSULFONYLATION; SYNTHETIC APPLICATIONS;

D O I：

10.1039/c7qo00729a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A visible-light-induced, Rose Bengal catalyzed photoredox process for synthesizing beta-acetylamino acrylosulfones has been discovered. This transformation represents an efficient and attractive method for synthesizing beta-acetylamino acrylosulfones from sodium sulfinates and enamides under transition-metalfree conditions in moderate to good yields. In addition, it exhibits a good substrate scope and functional group tolerance. The use of inexpensive organic dye Rose Bengal as the photocatalyst with easy operation at room temperature makes this protocol very practical.

引用

页码：92 / 97

页数：6

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