Senescence and aging: Causes, consequences, and therapeutic avenues

被引：852

作者：

McHugh, Domhnall ^{[1
,2
]}

Gil, Jesus ^{[1
,2
]}

机构：

[1] London Inst Med Sci, Med Res Council, London, England

[2] Imperial Coll London, Fac Med, Inst Clin Sci, London, England

来源：

JOURNAL OF CELL BIOLOGY | 2018年 / 217卷 / 01期

基金：

英国医学研究理事会;

关键词：

DNA-DAMAGE-RESPONSE; DEMETHYLASE JMJD3 CONTRIBUTES; HEMATOPOIETIC STEM-CELLS; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; IN-VIVO; LIFE-SPAN; CHONDROCYTE SENESCENCE; INK4A/ARF EXPRESSION; CHRONIC INFLAMMATION;

D O I：

10.1083/jcb.201708092

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biological basis of aging, research suggests that targeting the aging process itself could ameliorate many age-related pathologies. Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease. In this regard, recent experimental evidence has shown that the genetic or pharmacological ablation of senescent cells extends life span and improves health span. Here, we review the cellular and molecular links between cellular senescence and aging and discuss the novel therapeutic avenues that this connection opens.

引用

页码：65 / 77

页数：13

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