DNA binding behaviors and cleavage properties of a Ru(II) polypyridyl complex

被引：18

作者：

Liu, Xue-Wen ^{[1
,2
]}

Lu, Ji-Ling ^{[1
]}

Chen, Yuan-Dao ^{[1
,2
]}

Li, Lin ^{[1
,2
]}

Zhang, Da-Shun ^{[1
]}

机构：

[1] Hunan Univ Arts & Sci, Coll Chem & Chem Engn, Changde 415000, Peoples R China

[2] Xiangtan Univ, Key Lab Environm Friendly Chem & Applicat, Minist Educ, Xiangtan 411105, Peoples R China

来源：

INORGANICA CHIMICA ACTA | 2011年 / 379卷 / 01期

关键词：

Ru(II) complex; DNA cleavage; Zinc(II); DNA-binding; MODIFIED DIPYRIDOPHENAZINE LIGANDS; RUTHENIUM(II) COMPLEXES; LIGHT SWITCH; DEOXYRIBONUCLEIC-ACID; PHOTOCLEAVAGE; MONONUCLEAR; HYDROLYSIS; BINUCLEAR; DPPZ;

D O I：

10.1016/j.ica.2011.08.058

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel complex, [Ru(phen)(2)pzip](2+) 1 (phen = 1,10-phenanthroline; pzip = 2-(pyrazine-2-yl)imidazo-[4,5-f][1,10]phenanthroline]), has been synthesized and characterized by elemental analysis, ES-MS, H-1 NMR. The DNA-binding behaviors of this complex were studied by spectroscopic methods and viscosity measurements. The results indicate that the complex can bind to CT-DNA in an intercalative mode. When irradiated at 365 nm, complex 1 can promote the cleavage of plasmid pBR322DNA. Furthermore, Zn2+ can trigger the DNA cleavage of complex 1 without irradiation. The mechanism studies revealed that the DNA cleavage by complex 1 in the presence of Zn2+ is likely to proceed via a hydrolytic cleavage process. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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