Secondary Metabolites with Cytotoxic Activities from Streptomyces sp. BM-8 Isolated from the Feces of Equus quagga

被引：1

作者：

Lu, Shengsheng ^{[1
,2
]}

Hu, Jianan ^{[1
]}

Xie, Xi ^{[1
,3
]}

Zhou, Runhong ^{[1
]}

Li, Fangfang ^{[1
,4
]}

Huang, Ruifeng ^{[1
]}

He, Jian ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Grp Peptides & Nat Prod Res, 1838 Guangzhou Ave North, Guangzhou 510515, Peoples R China

[2] Guangxi Med Univ, Dept Pharm, Affiliated Tumor Hosp, Nanning 530021, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 3, 63 Duobao Rd, Guangzhou 510150, Peoples R China

[4] Longtime Pharmaceut Co Ltd, Dept Biol Prod, Foshan 528225, Peoples R China

来源：

MOLECULES | 2021年 / 26卷 / 24期

基金：

中国国家自然科学基金;

关键词：

animal intestinal bacteria; Streptomyces sp; BM-8; secondary metabolites; aliphatic acid; cytotoxic activities;

D O I：

10.3390/molecules26247556

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new aliphatic acid, compound 1, together with six known metabolites, including nonactic acid (2), homononactic acid (3), ethyl homononactate (4), homononactylhomononactate (5), valinomycin (6), and cyclo-(Pro-Leu) (7), was isolated from the culture broth of Streptomyces sp. BM-8, an actinobacterial strain isolated from the feces of Equus quagga. The structures of these compounds were established by analyses of spectroscopic data, including 1D and 2D nuclear magnetic resonance spectra (NMR), as well as by HR-ESI-MS spectrometry and chemical derivative analyses. Additionally, a serial analogue of nonactic acid and homononacticacid (8-21) was synthesized. The cytotoxicity of 1-21 wastested against a panel of cancer cell lines, such as HT-29, MCF-7, A375 and K562, with MTT assay. In addition, the cytotoxicity tests revealed that 1 was less cytotoxic toward a panel of cancerous cells, as compared with valinomycin (6).

引用

页数：12

共 14 条

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