Heat-shock pretreatment prevents suppression of long-term potentiation induced by scopolamine in rat hippocampal CA1 synapses

被引：18
作者：
Lin, YW
Yang, HW
Min, MY
Chiu, TH [1 ]
机构：
[1] Natl Yang Ming Univ, Dept Physiol, Taipei 112, Taiwan
[2] Chung Shan Med Univ, Dept Life Sci, Taichung 406, Taiwan
[3] Chinese Med Coll, Dept Physiol, Taichung 404, Taiwan
来源：
BRAIN RESEARCH | 2004年 / 999卷 / 02期
关键词：
long-term potentiation; scopolamine; heat shock; hippocampus;
D O I：
10.1016/j.brainres.2003.11.057
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the effect of heat-shock pretreatment on long-term potentiation (LTP) in the CA1 hippocampal slices of the rat using the muscarinic blocker scopolamine as the UP (memory) suppressor. Time course study using immunohistochemical techniques indicated peak expression of HSP70 16 h after heat-shock treatment. Focusing on that time point we found tetanic stimulation (at 100 Hz) induced LTP of 191.1 +/- 12.2% in control slices (n = 7), which was suppressed by scopolamine to 114.5 +/- 2.8 %. Heat-shock pretreatment successfully prevented such suppression (216.6 +/- 38.2%, and 190.2 +/- 10.6% with and without scopolamine, respectively, n = 7). Both HSP expression and LTP responses were relatively small taken either 2 or 48 h after heat-shock or sham pretreatment. These results suggest that the induction of HSPs is time-dependent and can prevent scopolamine-mediated UP suppression. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：222 / 226
页数：5
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