Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism

被引：135
作者：
Lawan, Ahmed [1 ]
Bennett, Anton M. [1 ,2 ]
机构：
[1] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA
[2] Yale Univ, Program Integrat Cell Signaling & Neurobiol Metab, New Haven, CT 06520 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 12期
基金：
美国国家卫生研究院;
关键词：
NONALCOHOLIC FATTY LIVER; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; STRESS-RESPONSE; JNK ACTIVATION; P38; INFLAMMATION; PHOSPHATASE; PATHWAYS;
D O I：
10.1016/j.tem.2017.10.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mitogen-activated protein kinases (MAPKs) participate in a multitude of processes that control hepatic metabolism. The liver regulates glucose and lipid metabolism, and under pathophysiological conditions such as obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD) these processes become dysfunctional. Stress responses activate the hepatic MAPKs, and this is thought to impair insulin action and lipid metabolism. The MAPKs also activate the MAPK phosphatases (MKPs) which oppose their actions. How the MAPK/MKP balance is controlled in liver metabolism and how perturbations in these activities contribute to metabolic disease remains unclear. Discussion of recent insights into the MAPK/MKP signaling role in hepatic metabolic function and disease will be the focus of this review.
引用
收藏
页码：868 / 878
页数：11
相关论文
共 58 条
[1]   Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1 [J].
Asada, Sachie ;
Daitoku, Hiroaki ;
Matsuzaki, Hitomi ;
Saito, Tomoko ;
Sudo, Tatsuhiko ;
Mukai, Hidehito ;
Iwashita, Shintaro ;
Kako, Koichiro ;
Kishi, Tsutomu ;
Kasuya, Yoshitoshi ;
Fukamizu, Akiyoshi .
CELLULAR SIGNALLING, 2007, 19 (03) :519-527
[2]   p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor α -: A potential role in the cardiac metabolic stress response [J].
Barger, PM ;
Browning, AC ;
Garner, AN ;
Kelly, DP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (48) :44495-44501
[3]   MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network [J].
Bhalla, US ;
Ram, PT ;
Iyengar, R .
SCIENCE, 2002, 297 (5583) :1018-1023
[4]   The isoform-specific functions of the c-Jun N-terminal kinases (JNKs): differences revealed by gene targeting [J].
Bogoyevitch, Marie A. .
BIOESSAYS, 2006, 28 (09) :923-934
[5]   The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis [J].
Bost, F ;
Aouadi, M ;
Caron, L ;
Even, P ;
Belmonte, N ;
Prot, M ;
Dani, C ;
Hofman, P ;
Pagès, G ;
Pouysségur, J ;
Le Marchand-Brustel, Y ;
Binétruy, B .
DIABETES, 2005, 54 (02) :402-411
[6]   The role of MAPKs in adipocyte differentiation and obesity [J].
Bost, F ;
Aouadi, M ;
Caron, L ;
Binétruy, B .
BIOCHIMIE, 2005, 87 (01) :51-56
[7]   Mitogen-activated protein (MAP) Kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer [J].
Boutros, Tarek ;
Chevet, Eric ;
Metrakos, Peter .
PHARMACOLOGICAL REVIEWS, 2008, 60 (03) :261-310
[8]   p38 mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis [J].
Cao, WH ;
Collins, QF ;
Becker, TC ;
Robidoux, J ;
Lupo, EG ;
Xiong, Y ;
Daniel, KW ;
Floering, L ;
Collins, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (52) :42731-42737
[9]   Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases [J].
Cargnello, Marie ;
Roux, Philippe P. .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2011, 75 (01) :50-83
[10]   Dual-specificity MAP kinase phosphatases (MKPs): Shaping the outcome of MAP kinase signalling [J].
Caunt, Christopher J. ;
Keyse, Stephen M. .
FEBS JOURNAL, 2013, 280 (02) :489-504
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