Mineralocorticoids modulate the expression of the-3 subunit of the Na+, K+-ATPase in the renal collecting duct

被引：1

作者：

Rojas, Macarena ^{[1
]}

Diaz, Pablo ^{[1
]}

Leon, Pablo ^{[1
]}

Gonzalez, Alexis A. ^{[2
]}

Gonzalez, Magdalena ^{[1
]}

Barrientos, Victor ^{[1
]}

Pestov, Nikolay B. ^{[3
,4
,5
]}

Alzamora, Rodrigo ^{[1
,6
]}

Michea, Luis ^{[1
,7
]}

机构：

[1] Univ Chile, Fac Med, Inst Ciencias Biomed, Santiago, Chile

[2] Pontificia Univ Catolica Valparaiso, Inst Quim, Valparaiso, Chile

[3] Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow, Russia

[4] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, 2801 W Bancroft St, Toledo, OH 43606 USA

[5] Univ Toledo, Coll Med, Ctr Diabet & Endocrine Res, 2801 W Bancroft St, Toledo, OH 43606 USA

[6] Millennium Nucleus Ion Channels Associated Dis Mi, Santiago, Chile

[7] Millennium Inst Immunol & Immunotherapy, Santiago, Chile

来源：

CHANNELS | 2017年 / 11卷 / 05期

关键词：

aldosterone; epithelial sodium channel; hypertension; intercalated cells; pendrin; principal cells; sodium pump; BETA; 3; SUBUNIT; ADHESION MOLECULE; PRINCIPAL CELLS; SODIUM-PUMP; NA; K-ATPASE; ALDOSTERONE; RECEPTOR; HETEROGENEITY; MECHANISM; K-PUMP;

D O I：

10.1080/19336950.2017.1344800

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Renal sodium reabsorption depends on the activity of the Na+,K+-ATPase / heterodimer. Four ((1-4)) and 3 ((1-3)) subunit isoforms have been described. It is accepted that renal tubule cells express (1)/(1) dimers. Aldosterone stimulates Na+,K+-ATPase activity and may modulate (1)/(1) expression. However, some studies suggest the presence of (3) in the kidney. We hypothesized that the (3) isoform of the Na+,K+-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. We found that (3) is highly expressed in collecting duct of rodents, and that mineralocorticoids decreased the expression of (3). Thus, we describe a novel molecular mechanism of sodium pump modulation that may contribute to the effects of mineralocorticoids on sodium reabsorption.

引用

页码：388 / 398

页数：11

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