Neural correlates of unconditioned response diminution during Pavlovian conditioning

被引：91

作者：

Dunsmoor, Joseph E. ^{[1
]}

Bandettini, Peter A. ^{[1
]}

Knight, David C. ^{[1
]}

机构：

[1] NIMH, Lab Brain & Cognit, Sect Funct Imaging Methods, Bethesda, MD 20892 USA

来源：

NEUROIMAGE | 2008年 / 40卷 / 02期

关键词：

UCR diminution; fear; conditioning; fMRI; learning; amygdala;

D O I：

10.1016/j.neuroimage.2007.11.042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pavlovian conditioning research has shown that unconditioned responses (UCR) to aversive unconditioned stimuli (UCS) are reduced when a UCS is predictable. This effect is known as UCR diminution. In the present study, we examined UCR diminution in the functional magnetic resonance imaging (fMRI) signal by varying the rate at which a neutral conditioned stimulus (CS) was paired with an aversive UCS. UCR diminution was observed within several brain regions associated with fear learning, including the amygdala, anterior cingulate, auditory cortex, and dorsolateral prefrontal cortex when a CS continuously relative to intermittently predicted the UCS. In addition, an inverse relationship between UCS expectancy and UCR magnitude was observed within the amygdala, anterior cingulate, and dorsolateral prefrontal cortex, such that as UCS expectancy increased the UCR decreased. These findings demonstrate UCR diminution within the fMRI signal, and suggest that UCS expectancies modulate UCR magnitude. Published by Elsevier Inc.

引用

页码：811 / 817

页数：7

共 50 条

[21] Children with Specific Language Impairment are not impaired in the acquisition and retention of Pavlovian delay and trace conditioning of the eyeblink response [J].

Hardiman, Mervyn J. ;

Hsu, Hsin-jen ;

Bishop, Dorothy V. M. .

BRAIN AND LANGUAGE, 2013, 127 (03) :428-439

[22] The association between the 5-HTTLPR and neural correlates of fear conditioning and connectivity [J].

Klucken, Tim ;

Schweckendiek, Jan ;

Blecker, Carlo ;

Walter, Bertram ;

Kuepper, Yvonne ;

Hennig, Juergen ;

Stark, Rudolf .

SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2015, 10 (05) :700-707

[23] Amygdalar unit activity during three learning tasks: Eyeblink classical conditioning, Pavlovian fear conditioning, and signaled avoidance conditioning [J].

Rorick-Kehn, LM ;

Steinmetz, JE .

BEHAVIORAL NEUROSCIENCE, 2005, 119 (05) :1254-1276

[24] Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning [J].

Fiocchi, Francesca Romana ;

van Dorp, Nikki E. S. ;

Dijkhuizen, Stephanie ;

van den Berg, Maurits ;

Wong, Aaron ;

De Zeeuw, Chris I. ;

Boele, Henk-Jan .

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2024, 18

[25] Synapses Lacking Astrocyte Appear in the Amygdala During Consolidation of Pavlovian Threat Conditioning [J].

Ostroff, Linnaea E. ;

Manzur, Mustfa K. ;

Cain, Christopher K. ;

Ledoux, Joseph E. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2014, 522 (09) :2152-2163

[26] Evidence for Model-based Computations in the Human Amygdala during Pavlovian Conditioning [J].

Prevost, Charlotte ;

McNamee, Daniel ;

Jessup, Ryan K. ;

Bossaerts, Peter ;

O'Doherty, John P. .

PLOS COMPUTATIONAL BIOLOGY, 2013, 9 (02)

[27] Acquisition of Pavlovian Fear Conditioning Using β-Adrenoceptor Activation of the Dorsal Premammillary Nucleus as an Unconditioned Stimulus to Mimic Live Predator-Threat Exposure [J].

Pavesi, Eloisa ;

Canteras, Newton S. ;

Carobrez, Antonio P. .

NEUROPSYCHOPHARMACOLOGY, 2011, 36 (05) :926-939

[28] Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing [J].

Tam, Shu K. E. ;

Bonardi, Charlotte .

BEHAVIOURAL BRAIN RESEARCH, 2012, 230 (01) :259-267

[29] Aversive Pavlovian Conditioning in Childhood Anxiety Disorders: Impaired Response Inhibition and Resistance to Extinction [J].

Waters, Allison M. ;

Henry, Julie ;

Neumann, David L. .

JOURNAL OF ABNORMAL PSYCHOLOGY, 2009, 118 (02) :311-321

[30] Neural correlates of naturalistic single-trial appetitive conditioning [J].

Davies-Owen, Jennifer A. ;

Stancak, Andrej ;

Giesbrecht, Timo ;

Thomas, Anna ;

Kirkham, Tim C. ;

Roberts, Carl A. .

PHYSIOLOGY & BEHAVIOR, 2023, 271

← 1 2 3 4 5 →