Pharmacokinetics of oral gabapentin alone or co-administered with meloxicam in ruminant beef calves

Gabapentin is a gamma-aminobutyric acid (GABA) analogue indicated for treatment of neuropathic pain. This study determined the pharmacokinetics of oral (PO) gabapentin alone or in combination with meloxicam in ruminant calves. Gabapentin capsules at 10 mg/kg or gabapentin powder (from capsules at 15 mg/kg) and meloxicam tablets (0.5 mg/kg) were administered PO to six beef calves. Plasma drug concentrations were determined over 48 h post-administration by liquid chromatography/mass spectrometry followed by non-compartmental pharmacokinetic analysis. The mean (+/- standard deviation, SD) C-max, T-max and elimination half-life (t(1/2)lambda z) for gabapentin (10 mg/kg) alone was 2.97 +/- 0.40 mu g/mL, 9.33 +/- 2.73 h and 11.02 +/- 3.68 h, respectively. The mean (+/- SD) C-max, T-max and t(1/2)lambda z for gabapentin (15 mg/kg) co-administered with meloxicam was 3.57 +/- 1.04 mu g/mL, 7.33 +/- 1.63 h and 8.12 +/- 2.11 h, respectively. The mean (+/- SD) C-max, T-max and t(1/2)lambda z for meloxicam was 2.11 +/- 0.19 mu g/mL, 11.67 +/- 3.44 h and 20.47 +/- 9.22 h, respectively. Plasma gabapentin concentrations >2 mu g/mL were maintained for up to 15 h and meloxicam concentrations >0.2 mu g/mL for up to 48 h. The pharmacokinetic profile of oral gabapentin and meloxicam supported clinical evaluation of these compounds for management of neuropathic pain in cattle. (C) 2010 Elsevier Ltd. All rights reserved.