Diagnostic and Therapeutic Considerations Towards Dientamoeba fragilis in Children: A Survey Amongst General Practitioners and Pediatricians in the Netherlands

被引：1
作者：
van Kalleveen, Michael W. [1 ,2 ]
van Bergen, Merel [3 ]
Benninga, Marc A. [3 ]
Savelkoul, Paul H. M. [4 ,5 ]
Plotz, Frans B. [1 ,6 ]
de Meij, Tim G. J. [3 ]
机构：
[1] Tergooi Hosp, Dept Pediat, Blaricum, Netherlands
[2] Leiden Univ, Dept Gastroenterol & Hepatol, Med Ctr, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
[3] Amsterdam UMC, Dept Pediat Gastroenterol, Emma Childrens Hosp, Amsterdam, Netherlands
[4] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Med Microbiol, Med Ctr, Maastricht, Netherlands
[5] Amsterdam UMC, Locat VUmc, Dept Med Microbiol & Infect Control, Amsterdam, Netherlands
[6] Univ Amsterdam, Emmas Childrens Hosp, Dept Pediat, Amsterdam UMC, Amsterdam, Netherlands
来源：
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2021年 / 73卷 / 06期
关键词：
children; diagnostics; Dientamoeba fragilis; management; therapy;
D O I：
10.1097/MPG.0000000000003297
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
This survey was undertaken to obtain insight in the attitude of Dutch physicians towards pathogenicity, diagnostic- and therapeutic approach towards Dientamoeba fragilis in children. Physicians were invited by e-mail for a questionnaire. A total of 211 of 450 physicians (46.9%) completed the questionnaire, including 67 general practitioners (GPs) and 144 pediatricians. Of all respondents, 175 of 211 (82.9%) considered D fragilis a "potential pathogen", when other causes of gastro-intestinal complaints are ruled out. Only 16 of 211 (7.6%) performed diagnostic tests regularly. Diagnostic tests were performed by 162 of 211 (77%) of respondents in children with diarrhea and abdominal pain in consideration of duration of symptoms. Fecal polymerase chain reaction (PCR) was diagnostic modality of preference. Eighty-nine of 142 (62.7%) prescribed metronidazole as antibiotic of first choice. This study shows heterogeneity in clinical practice amongst Dutch physicians regarding diagnostic- and therapeutic approach of D fragilis in children. Different attitude towards pathogenicity and inconsistent guidelines could be causative factors.
引用
收藏
页码：E121 / E125
页数：5
相关论文
共 20 条
[11]   Cyst formation and faecal-oral transmission of Dientamoeba fragilis - the missing link in the life cycle of an emerging pathogen [J].
Munasinghe, Varuni S. ;
Vella, Nicole G. F. ;
Ellis, John T. ;
Windsor, Peter A. ;
Stark, Damien .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2013, 43 (11) :879-883
[12]   Current treatment options for Dientamoeba fragilis infections [J].
Nagata, Noriyuki ;
Marriott, Deborah ;
Harkness, John ;
Ellis, John T. ;
Stark, Damien .
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE, 2012, 2 :204-215
[13]   Metronidazole Therapy for Treating Dientamoebiasis in Children Is Not Associated With Better Clinical Outcomes: A Randomized, Double-Blinded and Placebo-Controlled Clinical Trial [J].
Roser, Dennis ;
Simonsen, Jacob ;
Stensvold, Christen Rune ;
Olsen, Katharina E. P. ;
Bytzer, Peter ;
Nielsen, Henrik V. ;
Molbak, Kare .
CLINICAL INFECTIOUS DISEASES, 2014, 58 (12) :1692-1699
[14]  
Rutten J M T M, 2017, Ned Tijdschr Geneeskd, V161, pD781
[15]   Dientamoeba fragilis, the Neglected Trichomonad of the Human Bowel [J].
Stark, Damien ;
Barratt, Joel ;
Chan, Douglas ;
Ellis, John T. .
CLINICAL MICROBIOLOGY REVIEWS, 2016, 29 (03) :553-580
[16]   A Review of the Clinical Presentation of Dientamoebiasis [J].
Stark, Damien ;
Barratt, Joel ;
Roberts, Tamalee ;
Marriott, Deborah ;
Harkness, John ;
Ellis, John .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2010, 82 (04) :614-619
[17]  
van Gestel RSFE, 2019, PARASITOLOGY, V146, P1131, DOI [10.1017/S0031182018001385, 10.1017/s0031182018001385]
[18]   Intestinal Microbiota in Children With Symptomatic Dientamoeba fragilis Infection: A Case-control Study [J].
van Kalleveen, Michael W. ;
Budding, Andries E. ;
Benninga, Marc A. ;
Savelkoul, Paul H. M. ;
van Gool, Tom ;
van Maldeghem, Iris ;
Dorigo-Zetsma, J. W. ;
Bart, Aldert ;
Ploetz, Frans B. ;
de Meij, Tim G. J. .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2021, 40 (04) :279-283
[19]   Dientamoeba fragilis in children: a systematic review on diagnostic considerations and efficacy of treatment [J].
van Kalleveen, Michael W. ;
van Gool, Tom ;
Klarenbeek, Nikki ;
Benninga, Marc A. ;
Savelkoul, Paul H. M. ;
de Meij, Tim ;
Plotz, Frans B. .
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2020, 14 (04) :231-242
[20]   Does Dientamoeba fragilis cause diarrhea? A systematic review [J].
Wong, Zing-Wae ;
Faulder, Kate ;
Robinson, Joan L. .
PARASITOLOGY RESEARCH, 2018, 117 (04) :971-980
12