Bone morphogenetic protein signaling in musculoskeletal cancer

被引：15

作者：

Bami, Myrto ^{[3
]}

Mavrogenis, Andreas F. ^{[1
]}

Angelini, Andrea ^{[2
]}

Milonaki, Mandy ^{[3
]}

Mitsiokapa, Evanthia ^{[3
]}

Stamoulis, Dimitrios ^{[3
]}

Soucacos, Panayotis N. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Attikon Univ Hosp, Dept Orthopaed 1, Athens, Greece

[2] Univ Bologna, Dept Orthopaed, Ist Ortoped Rizzoli, Via Pupilli 1, I-40136 Bologna, Italy

[3] Univ Athens, Sch Med, Attikon Univ Hosp, Orthopaed Res & Educ Ctr, Athens, Greece

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2016年 / 142卷 / 10期

关键词：

Bone morphogenetic proteins; Cancer; Musculoskeletal; Bone tumors; METASTATIC PROSTATE-CANCER; HUMAN OSTEOSARCOMA CELLS; FACTOR-BETA SUPERFAMILY; OSTEOBLAST-LIKE CELLS; BREAST-CANCER; GROWTH-FACTOR; IN-VITRO; STEM-CELLS; IMMUNOHISTOCHEMICAL DETECTION; CHONDROCYTE PROLIFERATION;

D O I：

10.1007/s00432-016-2149-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta (TGF-beta) superfamily of proteins; they were initially named after their ability to induce ectopic bone formation. Published studies have proved BMPs' role in a variety of biological processes such as embryogenesis and patterning of body axes, and maintaining adult tissue homeostasis. Other studies have focused on BMPs properties, functions and possible involvement in skeletal diseases, including cancer. A literature search mainly paying attention to the role of BMPs in musculoskeletal tumors was performed in electronic databases. This article discusses BMPs synthesis and signaling, and summarizes their prominent roles in the skeletal system for the differentiation of osteoblasts, osteocytes and chondrocytes. The review emphasizes on the role of BMP signaling in the initiation and progression of musculoskeletal cancer.

引用

页码：2061 / 2072

页数：12

共 113 条

[1] Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas [J].

Alarmo, E. -L. ;

Korhonen, T. ;

Kuukasjaervi, T. ;

Huhtala, H. ;

Holli, K. ;

Kallioniemi, A. .

ANNALS OF ONCOLOGY, 2008, 19 (02) :308-314

[2] BMP7 influences proliferation, migration, and invasion of breast cancer cells [J].

Alarmo, Emma-Leena ;

Parssinen, Jenita ;

Ketolainen, Johanna M. ;

Savinainen, Kimmo ;

Karhu, Ritva ;

Kallioniemi, Anne .

CANCER LETTERS, 2009, 275 (01) :35-43

[3] The "bone morphogenic proteins" pathways in bone and joint diseases: Translational perspectives from physiopathology to therapeutic targets [J].

Biver, Emmanuel ;

Hardouin, Pierre ;

Caverzasio, Joseph .

CYTOKINE & GROWTH FACTOR REVIEWS, 2013, 24 (01) :69-81

[4] Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro [J].

Bobacz, K ;

Gruber, R ;

Soleiman, A ;

Erlacher, L ;

Smolen, JS ;

Graninger, WB .

ARTHRITIS AND RHEUMATISM, 2003, 48 (09) :2501-2508

[5]

Bobinac D, 2005, CROAT MED J, V46, P389

[6] BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors [J].

Boeuf, Stephane ;

Bovee, Judith V. M. G. ;

Lehner, Burkhard ;

van den Akker, Brendy ;

van Ruler, Maayke ;

Cleton-Jansen, Anne-Marie ;

Richter, Wiltrud .

BMC CANCER, 2012, 12

[7] The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation [J].

Buijs, J. T. ;

van der Horst, G. ;

van den Hoogen, C. ;

Cheung, H. ;

de Rooij, B. ;

Kroon, J. ;

Petersen, M. ;

van Overveld, P. G. M. ;

Pelger, R. C. M. ;

van der Pluijm, G. .

ONCOGENE, 2012, 31 (17) :2164-2174

[8] BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo [J].

Buijs, Jeroen T. ;

Rentsch, Cyrill A. ;

van der Horst, Geertje ;

van Civerveld, Petra G. M. ;

Wetterwald, Antoinette ;

Schwaninger, Ruth ;

Henriquez, Niek V. ;

ten Dijke, Peter ;

Borovecki, Fran ;

Markwalder, Regula ;

Thalmann, George N. ;

Papapoulos, Socrates E. ;

Pelger, Rob C. M. ;

Vukicevic, Slobodan ;

Cecchini, Marco G. ;

Lowik, Clemens W. G. M. ;

van der Pluijm, Gabri .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (03) :1047-1057

[9] BMP-7 Enhances Cell Migration and αvβ3 Integrin Expression via a c-Src-Dependent Pathway in Human Chondrosarcoma Cells [J].

Chen, Jui-Chieh ;

Yang, Shu-Ting ;

Lin, Chih-Yang ;

Hsu, Chin-Jung ;

Tsai, Chun-Hao ;

Su, Jen-Liang ;

Tang, Chih-Hsin .

PLOS ONE, 2014, 9 (11)

[10] Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs) [J].

Cheng, HW ;

Jiang, W ;

Phillips, FM ;

Haydon, RC ;

Peng, Y ;

Zhou, L ;

Luu, HH ;

An, NL ;

Breyer, B ;

Vanichakarn, P ;

Szatkowski, JP ;

Park, JY ;

He, TC .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2003, 85A (08) :1544-1552

← 1 2 3 4 5 6 7 8 9 10 →