Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects

被引：63

作者：

Song, Cong-ying ^{[1
,2
,3
]}

Xu, Ying-ge ^{[1
,2
,3
]}

Lu, Yuan-qiang ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Emergency Med, Hangzhou 310003, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Geriatr Med, Hangzhou 310003, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Zhejiang Prov Key Lab Diag & Treatment Aging & Ph, Hangzhou 310003, Peoples R China

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2020年 / 21卷 / 04期

关键词：

Tripterygium wilfordii Hook F; Anti-inflammation; Immunosuppression; R285; ENDOTHELIAL BARRIER DYSFUNCTION; RHEUMATOID-ARTHRITIS; TRIPTOLIDE; EXPRESSION; INHIBITION; CELASTROL; MECHANISM; EFFICACY; INJURY; CELLS;

D O I：

10.1631/jzus.B1900607

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tripterygium wilfordii Hook F has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and kidney disease, especially in traditional Chinese medicine. The mechanisms underlying its effects may be diverse but they remain unclear, and its toxicity and side effects limit its wider clinical application. This review summarizes the clinical application of Tripterygium wilfordii Hook F in recent years, as well as the results of studies into its mechanisms and toxicity, to provide a reference for its future clinical application.

引用

页码：280 / 290

页数：11

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