Metabolites: messengers between the microbiota and the immune system

被引：347

作者：

Levy, Maayan ^{[1
]}

Thaiss, Christoph A. ^{[1
]}

Elinav, Eran ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

GENES & DEVELOPMENT | 2016年 / 30卷 / 14期

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

immune; metabolites; microbiome; ARYL-HYDROCARBON RECEPTOR; CHAIN FATTY-ACIDS; REGULATORY T-CELLS; GUT MICROBIOTA; RETINOIC-ACID; VITAMIN-D; DENDRITIC CELLS; AMINO-ACID; SMALL-INTESTINE; COMMENSAL;

D O I：

10.1101/gad.284091.116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian intestine harbors one of the largest microbial densities on Earth, necessitating the implementation of control mechanisms by which the host evaluates the state of microbial colonization and reacts to deviations from homeostasis. While microbial recognition by the innate immune system has been firmly established as an efficient means by which the host evaluates microbial presence, recent work has uncovered a central role for bacterial metabolites in the orchestration of the host immune response. In this review, we highlight examples of how microbiota-modulated metabolites control the development, differentiation, and activity of the immune system and classify them into functional categories that illustrate the spectrum of ways by which microbial metabolites influence host physiology. A comprehensive understanding of how microbiota-derived metabolites shape the human immune system is critical for the rational design of therapies for microbiota-driven diseases.

引用

页码：1589 / 1597

页数：9

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