Caveolin, caveolae, and endothelial cell function

被引：293

作者：

Frank, PG ^{[1
]}

Woodman, SE ^{[1
]}

Park, DS ^{[1
]}

Lisanti, MP ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2003年 / 23卷 / 07期

关键词：

caveolae; endothelial cells; transcytosis; angiogenesis; atherosclerosis;

D O I：

10.1161/01.ATV.0000070546.16946.3A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in terminally differentiated cells. They are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking and signal transduction. The use of caveolin-1-deficient mice has provided many new insights into the roles of caveolae and caveolin-1 in the regulation of endothelial cell function. These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease.

引用

页码：1161 / 1168

页数：8

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