p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters

被引：95
作者：
Fischer, C. A. [1 ]
Kampmann, M. [1 ]
Zlobec, I. [2 ]
Green, E. [1 ]
Tornillo, L. [2 ]
Lugli, A. [2 ]
Wolfensberger, M. [1 ]
Terracciano, L. M. [2 ]
机构：
[1] Univ Basel Hosp, Dept Otolaryngol Head & Neck Surg, CH-4031 Basel, Switzerland
[2] Univ Basel Hosp, Dept Pathol, CH-4031 Basel, Switzerland
来源：
ANNALS OF ONCOLOGY | 2010年 / 21卷 / 10期
关键词：
HPV; oropharyngeal carcinoma; p16; prognosis; staging; SQUAMOUS-CELL CARCINOMA; GENE-EXPRESSION; HPV-DNA; HEAD; SURVIVAL; RISK; CHEMOTHERAPY; SUBSET; TONGUE; P53;
D O I：
10.1093/annonc/mdq210
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Patients and methods: Immunohistochemistry for p16 was carried out on the basis of a tissue microarray including 102 OPSCC patients with corresponding retrospective clinicopathological and follow-up data. Results: p16 is the strongest independent prognostic marker in OPSCC, surpassing the significance of cT and cN classification as well as the clinical stages I-IV. Prognosis of p16-positive OPSCC of an advanced stage reached or even exceeded prognosis of the next clinically smaller conventionally staged group of tumors. Conclusion: p16 is the most relevant prognostic marker in OPSCC and should be considered for inclusion into the official staging system of HNSCC.
引用
收藏
页码：1961 / 1966
页数：6
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