Impact of estrogens and estrogen receptor-α in brain lipid metabolism

被引：43

作者：

Morselli, Eugenia ^{[1
]}

Santos, Roberta de Souza ^{[2
]}

Gao, Su ^{[2
,3
]}

Avalos, Yenniffer ^{[1
]}

Criollo, Alfredo ^{[4
,5
,6
]}

Palmer, Biff F. ^{[7
]}

Clegg, Deborah J. ^{[2
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Biol Sci, Dept Physiol, Ave Libertador Bernardo OHiggings 340, Santiago 8331150, Chile

[2] Cedars Sinai Diabet & Obes Res Inst, Dept Biomed Res, Los Angeles, CA USA

[3] Columbia Univ, Dept Med, Med Ctr, New York, NY USA

[4] Adv Ctr Chron Dis, Santiago, Chile

[5] Ctr Mol Studies Cell, Santiago, Chile

[6] Univ Chile, Fac Odontol, Inst Invest Ciencias Odontol, Santiago, Chile

[7] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2018年 / 315卷 / 01期

关键词：

Alzheimer's disease; estrogens; fatty acid oxidation; fatty acids; sexual dimorphism; ACTIVATED PROTEIN-KINASE; FATTY-ACID-METABOLISM; HYPOTHALAMIC MALONYL-COA; ADIPOSE-TISSUE; SEX-DIFFERENCES; FOOD-INTAKE; ENERGY-BALANCE; ER-ALPHA; LIPOPROTEIN-LIPASE; SKELETAL-MUSCLE;

D O I：

10.1152/ajpendo.00473.2017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose tissues, for which much is known. An area of estrogenic research that has received less attention is the role of estrogens and their receptors in influencing intermediary lipid metabolism in organs such as the brain. In this review, we highlight the actions of estrogens and their receptors in regulating their impact on modulating fatty acid content, utilization, and oxidation through their direct impact on intracellular signaling cascades within the central nervous system.

引用

页码：E7 / E14

页数：8

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