Triterpene Composition and Bioactivities of Centella asiatica

被引：164

作者：

Hashim, Puziah ^{[1
]}

Sidek, Hamidah ^{[2
]}

Helan, Mohd Helme M. ^{[2
]}

Sabery, Aidawati ^{[2
]}

Palanisamy, Uma Devi ^{[3
]}

Ilham, Mohd ^{[4
]}

机构：

[1] Univ Putra Malaysia, Halal Prod Res Inst, Upm Serdang 43400, Selangor, Malaysia

[2] SIRIM Berhad, Ind Biotechnol Res Ctr, Shah Alam 40911, Selangor, Malaysia

[3] Monash Univ, Sch Med & Hlth Sci, Bandar Sunway 46150, Selangor, Malaysia

[4] Forest Res Inst Malaysia, Kepong 52109, Selangor, Malaysia

来源：

MOLECULES | 2011年 / 16卷 / 02期

关键词：

Centella asiatica; triterpenes; collagen; anti-oxidant; UV protection; ANTIOXIDANT ACTIVITY; ACTIVE CONSTITUENTS; L URBAN; EXTRACTS; WOUNDS; PLANTS; MICE;

D O I：

10.3390/molecules16021310

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection capacity properties. Triterpenes of Centella were measured using HPLC-PAD on an Excil ODS 5 mu m (C18) column for the simultaneous determination of asiatic acid, madecassic acid, asiaticoside and madecassoside. Centella was found to contain significant amounts of madecassoside (3.10 +/- 4.58 mg/mL) and asiaticoside (1.97 +/- 2.65 mg/mL), but was low in asiatic and madecassic acid. The highest collagen synthesis was found at 50 mg/mL of Centella extracts. The antioxidant activity of Centella (84%) was compared to grape seed extract (83%) and Vitamin C (88%). Its lipolytic activity was observed by the release of glycerol (115.9 mu mol/L) at 0.02% concentration. Centella extracts exhibited similar UV protection effect to OMC at 10% concentration. In view of these results, the potential application of Centella in food and pharmaceutical industries is now widely open.

引用

页码：1310 / 1322

页数：13

共 44 条

[1]

[Anonymous], FOOD CHEM

[2] CYTOTOXIC AND ANTITUMOR PROPERTIES OF CERTAIN TAXA OF UMBELLIFERAE WITH SPECIAL REFERENCE TO CENTELLA-ASIATICA (L) URBAN [J].

BABU, TD ;

KUTTAN, G ;

PADIKKALA, J .

JOURNAL OF ETHNOPHARMACOLOGY, 1995, 48 (01) :53-57

[3] INFLUENCE OF ASIATIC ACID, MADECASSIC ACID, AND ASIATICOSIDE ON HUMAN COLLAGEN-I SYNTHESIS [J].

BONTE, F ;

DUMAS, M ;

CHAUDAGNE, C ;

MEYBECK, A .

PLANTA MEDICA, 1994, 60 (02) :133-135

[4]

Bonte F., 1995, Annales Pharmaceutiques Francaises, V53, P38

[5]

BOORAS CH, 1998, SPF UVB UVA PROTECTI

[6] Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica [J].

Brinkhaus, B ;

Lindner, M ;

Schuppan, D ;

Hahn, EG .

PHYTOMEDICINE, 2000, 7 (05) :427-448

[7] Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension:: Measurement by laser Doppler, TcPO2-CO2, and leg volumetry [J].

Cesarone, MR ;

Belcaro, G ;

Rulo, A ;

Griffin, M ;

Ricci, A ;

Ippolito, E ;

De Sanctis, MT ;

Incandela, L ;

Bavera, P ;

Cacchio, M ;

Bucci, M .

ANGIOLOGY, 2001, 52 :S45-S48

[8]

Chen Yao, 2003, Zhong Yao Cai, V26, P870

[9] Aloesin inhibits hyperpigmentation induced by UV radiation [J].

Choi, S ;

Park, YI ;

Lee, SK ;

Kim, JE ;

Chung, MH .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2002, 27 (06) :513-515

[10]

CHRIS IC, 2010, DIABETES VASC DIS RE, V6, P200

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