The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy

被引：0

作者：

Shan, Qingqing ^{[1
]}

Zhang, Yifan ^{[2
]}

Zhang, Xu ^{[2
]}

Wang, Wei ^{[2
]}

Liang, Zongan ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Chengdu, Peoples R China

[2] Chengdu First Peoples Hosp, Chengdu, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2022年 / 17卷 / 10期

关键词：

lung squamous cell carcinoma; bioinformatics analysis; prognosis; hub genes; coumestrol; CANCER-RISK; PROSTATE-CANCER; UNITED-STATES; PHYTOESTROGENS; PROLIFERATION; METABOLISM; TRENDS;

D O I：

10.1177/1934578X221127960

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Purpose There is limited treatment for lung squamous cell carcinoma (LUSC), so there is an urgent need to find new antitumor drugs. Materials and Methods We downloaded datasets from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas databases. We used GEO2R and the "limma" package to screen differentially expressed genes. We used the Cytoscape software to screen out hub genes. We screened herbs that act on hub genes on the Chinese medicine website. We then studied the effect of coumestrol (CM) on the hub genes in the H226 cell line. Results Seven hub genes were screened, namely CCNB2, CENPF, KIF11, MELK, nucleolar and spindle-associated protein 1 (NUSAP1), PBK, and RRM2. We observed that CM had a tumor-inhibiting effect on H226 cells by inhibiting the expression of CCNB2, KIF11, and NUSAP1. Conclusion CM, screened by bioinformatics and network pharmacology, can inhibit H226 cells by downregulating CCNB2, KIF11, and NUSAP1.

引用

页数：10

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