BGM-Net: Boundary-Guided Multiscale Network for Breast Lesion Segmentation in Ultrasound

被引:15
作者
Wu, Yunzhu [1 ]
Zhang, Ruoxin [2 ]
Zhu, Lei [3 ]
Wang, Weiming [4 ]
Wang, Shengwen [5 ,6 ]
Xie, Haoran [7 ]
Cheng, Gary [8 ]
Wang, Fu Lee [4 ]
He, Xingxiang [2 ]
Zhang, Hai [1 ,9 ]
机构
[1] Jinan Univ, Dept Ultrasound, Clin Coll 2, Shenzhen Peoples Hosp, Shenzhen, Peoples R China
[2] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou, Peoples R China
[3] Univ Cambridge, Dept Appl Math & Theoret Phys, Cambridge, England
[4] Open Univ Hong Kong, Sch Sci & Technol, Hong Kong, Peoples R China
[5] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Neurosurg, Guangzhou, Peoples R China
[6] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Peoples R China
[7] Lingnan Univ, Dept Comp & Decis Sci, Hong Kong, Peoples R China
[8] Educ Univ Hong Kong, Dept Math & Informat Technol, Hong Kong, Peoples R China
[9] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
基金
中国国家自然科学基金;
关键词
breast lesion segmentation; boundary-guided feature enhancement; multiscale image analysis; ultrasound image segmentation; deep learning; AUTOMATED SEGMENTATION; SNAKE MODEL; IMAGES; TUMOR;
D O I
10.3389/fmolb.2021.698334
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Automatic and accurate segmentation of breast lesion regions from ultrasonography is an essential step for ultrasound-guided diagnosis and treatment. However, developing a desirable segmentation method is very difficult due to strong imaging artifacts e.g., speckle noise, low contrast and intensity inhomogeneity, in breast ultrasound images. To solve this problem, this paper proposes a novel boundary-guided multiscale network (BGM-Net) to boost the performance of breast lesion segmentation from ultrasound images based on the feature pyramid network (FPN). First, we develop a boundary-guided feature enhancement (BGFE) module to enhance the feature map for each FPN layer by learning a boundary map of breast lesion regions. The BGFE module improves the boundary detection capability of the FPN framework so that weak boundaries in ambiguous regions can be correctly identified. Second, we design a multiscale scheme to leverage the information from different image scales in order to tackle ultrasound artifacts. Specifically, we downsample each testing image into a coarse counterpart, and both the testing image and its coarse counterpart are input into BGM-Net to predict a fine and a coarse segmentation maps, respectively. The segmentation result is then produced by fusing the fine and the coarse segmentation maps so that breast lesion regions are accurately segmented from ultrasound images and false detections are effectively removed attributing to boundary feature enhancement and multiscale image information. We validate the performance of the proposed approach on two challenging breast ultrasound datasets, and experimental results demonstrate that our approach outperforms state-of-the-art methods.
引用
收藏
页数:8
相关论文
共 36 条
[1]   Dataset of breast ultrasound images [J].
Al-Dhabyani, Walid ;
Gomaa, Mohammed ;
Khaled, Hussien ;
Fahmy, Aly .
DATA IN BRIEF, 2020, 28
[2]   Multiple resolution Bayesian segmentation of ultrasound images [J].
Ashton, EA ;
Parker, KJ .
ULTRASONIC IMAGING, 1995, 17 (04) :291-304
[3]  
Boukerroui D, 1998, Eur J Ultrasound, V8, P135, DOI 10.1016/S0929-8266(98)00062-7
[5]   Performance measure characterization for evaluating neuroimage segmentation algorithms [J].
Chang, Herng-Hua ;
Zhuang, Audrey H. ;
Valentino, Daniel J. ;
Chu, Woei-Chyn .
NEUROIMAGE, 2009, 47 (01) :122-135
[6]   Segmentation of breast tumor in three-dimensional ultrasound images using three-dimensional discrete active contour model [J].
Chang, RF ;
Wu, WJ ;
Moon, WK ;
Chen, WM ;
Lee, W ;
Chen, DR .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2003, 29 (11) :1571-1581
[7]   Cell-based dual snake model: A new approach to extracting highly winding boundaries in the ultrasound images [J].
Chen, CM ;
Lu, HHS ;
Huang, YS .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2002, 28 (08) :1061-1073
[8]   Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation [J].
Chen, Liang-Chieh ;
Zhu, Yukun ;
Papandreou, George ;
Schroff, Florian ;
Adam, Hartwig .
COMPUTER VISION - ECCV 2018, PT VII, 2018, 11211 :833-851
[9]   CELL-BASED GRAPH CUT FOR SEGMENTATION OF 2D/3D SONOGRAPHIC BREAST IMAGES [J].
Chiang, Hsin-Hung ;
Cheng, Jie-Zhi ;
Hung, Pei-Kai ;
Liu, Chun-You ;
Chung, Cheng-Hong ;
Chen, Chung-Ming .
2010 7TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO, 2010, :177-180
[10]   Phase- and GVF-Based Level Set Segmentation of Ultrasonic Breast Tumors [J].
Gao, Liang ;
Liu, Xiaoyun ;
Chen, Wufan .
JOURNAL OF APPLIED MATHEMATICS, 2012,