Pathogen-Negative Sepsis-An Opportunity for Antimicrobial Stewardship

被引：11

作者：

Lockhart, Gabriel C. ^{[1
]}

Hanin, Jacob ^{[2
]}

Micek, Scott T. ^{[3
]}

Kollef, Marin H. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA

[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[3] St Louis Coll Pharm, Dept Pharm Practice, St Louis, MO USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2019年 / 6卷 / 10期

关键词：

pathogen-negative; sepsis; stewardship; CLASSIFICATION; OUTCOMES;

D O I：

10.1093/ofid/ofz397

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sepsis is a common reason for empiric antibiotics among hospitalized patients. We found that the median duration of empiric antibiotics (interquartile range) was 6 (4-9) days among 1047 survivivors with pathogen-negative sepsis. These findings suggest that patients with pathogen-negative sepsis could represent an important opportunity for antimicrobial stewardship.

引用

页数：4

共 15 条

[1] Carbapenemase-Producing Organisms: A Global Scourge [J].

Bonomo, Robert A. ;

Burd, Eileen M. ;

Conly, John ;

Limbago, Brandi M. ;

Poirel, Laurent ;

Segre, Julie A. ;

Westblade, Lars F. .

CLINICAL INFECTIOUS DISEASES, 2018, 66 (08) :1290-1297

[2] Impact of Sepsis Classification and Multidrug-Resistance Status on Outcome Among Patients Treated With Appropriate Therapy [J].

Burnham, Jason P. ;

Lane, Michael A. ;

Kollef, Marin H. .

CRITICAL CARE MEDICINE, 2015, 43 (08) :1580-1586

[3] Culture-Negative Severe Sepsis Nationwide Trends and Outcomes [J].

Gupta, Shipra ;

Sakhuja, Ankit ;

Kumar, Gagan ;

McGrath, Eric ;

Nanchal, Rahul S. ;

Kashani, Kianoush B. .

CHEST, 2016, 150 (06) :1251-1259

[4] Burden of Pneumonia-Associated Hospitalizations United States, 2001-2014 [J].

Hayes, Brandon H. ;

Haberling, Dana L. ;

Kennedy, Jordan L. ;

Varma, Jay K. ;

Fry, Alicia M. ;

Vora, Neil M. .

CHEST, 2018, 153 (02) :427-437

[5] Infectious Diseases Society of America (IDSA) POSITION STATEMENT: Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines [J].

Kalil, Andre C. ;

Gilbert, David N. ;

Winslow, Dean L. ;

Masur, Henry ;

Klompas, Michael .

CLINICAL INFECTIOUS DISEASES, 2018, 66 (10) :1631-1635

[6] Antibiotic Thresholds for Sepsis and Septic Shock [J].

Kollef, Marin H. ;

Burnham, Jason P. .

CLINICAL INFECTIOUS DISEASES, 2019, 69 (06) :938-940

[7] A Comparison of Culture-Positive and Culture-Negative Health-Care-Associated Pneumonia [J].

Labelle, Andrew J. ;

Arnold, Heather ;

Reichley, Richard M. ;

Micek, Scott T. ;

Kollef, Marin H. .

CHEST, 2010, 137 (05) :1130-1137

[8] The Surviving Sepsis Campaign Bundle: 2018 update [J].

Levy, Mitchell M. ;

Evans, Laura E. ;

Rhodes, Andrew .

INTENSIVE CARE MEDICINE, 2018, 44 (06) :925-928

[9] Resistance patterns and outcomes in intensive care unit (ICU)-acquired pneumonia. Validation of European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC) classification of multidrug resistant organisms [J].

Martin-Loeches, Ignacio ;

Torres, Antonio ;

Rinaudo, Mariano ;

Terraneo, Silvia ;

de Rosa, Francesca ;

Ramirez, Paula ;

Diaz, Emili ;

Fernandez-Barat, Laia ;

Luigi Li Bassi, Gian ;

Ferrer, Miquel .

JOURNAL OF INFECTION, 2015, 70 (03) :213-222

[10] Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 [J].

Rhodes, Andrew ;

Evans, Laura E. ;

Alhazzani, Waleed ;

Levy, Mitchell M. ;

Antonelli, Massimo ;

Ferrer, Ricard ;

Kumar, Anand ;

Sevransky, Jonathan E. ;

Sprung, Charles L. ;

Nunnally, Mark E. ;

Rochwerg, Bram ;

Rubenfeld, Gordon D. ;

Angus, Derek C. ;

Annane, Djillali ;

Beale, Richard J. ;

Bellinghan, Geoffrey J. ;

Bernard, Gordon R. ;

Chiche, Jean-Daniel ;

Coopersmith, Craig ;

De Backer, Daniel P. ;

French, Craig J. ;

Fujishima, Seitaro ;

Gerlach, Herwig ;

Hidalgo, Jorge Luis ;

Hollenberg, Steven M. ;

Jones, Alan E. ;

Karnad, Dilip R. ;

Kleinpell, Ruth M. ;

Koh, Younsuck ;

Lisboa, Thiago Costa ;

Machado, Flavia R. ;

Marini, John J. ;

Marshall, John C. ;

Mazuski, John E. ;

McIntyre, Lauralyn A. ;

McLean, Anthony S. ;

Mehta, Sangeeta ;

Moreno, Rui P. ;

Myburgh, John ;

Navalesi, Paolo ;

Nishida, Osamu ;

Osborn, Tiffany M. ;

Perner, Anders ;

Plunkett, Colleen M. ;

Ranieri, Marco ;

Schorr, Christa A. ;

Seckel, Maureen A. ;

Seymour, Christopher W. ;

Shieh, Lisa ;

Shukri, Khalid A. .

CRITICAL CARE MEDICINE, 2017, 45 (03) :486-552

← 1 2 →