Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility

被引：10

作者：

He, Xin ^{[1
]}

Yang, Jing ^{[2
]}

Qiu, Ling ^{[1
]}

Feng, Dan ^{[1
]}

Ju, Feng ^{[1
]}

Tan, Lu ^{[1
]}

Li, Yu-Zhi ^{[1
]}

Gu, Yu-Cheng ^{[3
]}

Zhang, Zhen ^{[1
]}

Guo, Da-Le ^{[1
]}

Deng, Yun ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Breeding Base Systemat Res Dev & Utilizat Chinese, Key Lab Standardizat Chinese Herbal Med, Minist Educ,State Key Lab,Sch Pharm, Chengdu 611137, Sichuan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[3] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

MOLECULES | 2019年 / 24卷 / 02期

基金：

中国博士后科学基金;

关键词：

Penicillium crustosum; Isaria cicadae; thiodiketopiperazines; Mosher analysis; ECD calculation; gastrointestinal motility; DIKETOPIPERAZINES; POLYKETIDES;

D O I：

10.3390/molecules24020299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new thiodiketopiperazines (1-3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher ester analysis and calculated ECD spectra. Compound 4 and 5 have the activity to promote the gastrointestinal motility of zebrafish via acting on the cholinergic nervous system.

引用

页数：8

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