Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance

被引：33
作者：
Liu, Hong-Qi [1 ]
Song, Shu [2 ]
Wang, Jian-Hua [3 ]
Zhang, Shao-Lan [4 ]
机构：
[1] Yancheng First Peoples Hosp, Dept Oncol, Yancheng 224005, Jiangsu, Peoples R China
[2] Yancheng First Peoples Hosp, Dept Pathol, Yancheng 224005, Jiangsu, Peoples R China
[3] Yancheng First Peoples Hosp, Dept Gastroenterol, Dept Oncol, Yancheng 224005, Jiangsu, Peoples R China
[4] Yancheng Hlth Vocat & Tech Coll, Dept Med Technol, Yancheng 224006, Peoples R China
来源：
ONCOLOGY LETTERS | 2011年 / 2卷 / 06期
关键词：
gastric cancer; matrix metalloproteinase-3; tissue inhibitor of metalloproteinase-3; METALLOPROTEINASES (TIMP)-3; MATRIX METALLOPROTEINASES; PROGNOSTIC-SIGNIFICANCE; COLORECTAL-CANCER; TUMOR INVASION; INHIBITOR; METASTASIS; GROWTH;
D O I：
10.3892/ol.2011.399
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The present study aimed to investigate the expression of matrix metalloproteinase-3 (MMP-3) and the tissue inhibitor of metalloproteinase-3 (TIMP-3) in gastric cancer tissue, as well as to analyze the correlation between their expression and the occurrence of gastric cancer. Immunohistochemistry was used to determine the expression of MMP-3 and TIMP-3 in the gastric cancer tissue from 18 patients with early-stage gastric cancer (early-stage group) and 26 patients with advanced-stage gastric cancer (advanced-stage group). Transmission electron microscopy (TEM) was used to observe the lymphocytes and tumor cells in gastric cancer tissue. The results showed that the expression of TIMP-3 was significantly higher, whereas that of MMP-3 and MMP-3/TIMP-3 was lower in gastric cancer tissue of the early-stage group than in that of the advanced-stage group (P<0.05). The TEM images revealed increased lymphocytes and inconspicuous tumor cells penetrating the basement membrane in gastric cancer tissue of the early-stage group, and decreased lymphocytes and obvious tumor cells penetrating the basement membrane in the advanced-stage group. In conclusion, MMP-3 and TIMP-3 may be used as indices for the invasion and metastasis of gastric cancer and possess marked clinical significance in the prognostic judgment of gastric cancer.
引用
收藏
页码：1319 / 1322
页数：4
相关论文
共 16 条
[11]   Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: Relation to tumor phenotype and clinical outcome [J].
Mylona, Eleni ;
Magkou, Christina ;
Giannopoulou, Ioanna ;
Agrogiannis, George ;
Markaki, Sofia ;
Keramopoulos, Antonios ;
Nakopoulou, Lydia .
BREAST CANCER RESEARCH, 2006, 8 (05)
[12]  
Pietruszewska Wioletta, 2008, Otolaryngol Pol, V62, P380, DOI 10.1016/S0030-6657(08)70276-2
[13]  
Stetler-Stevenson W G, 2001, Surg Oncol Clin N Am, V10, P383
[14]  
Watanabe Hideto, 2010, Gan To Kagaku Ryoho, V37, P2058
[15]   Abnormal expression of early growth response 1 in gastric cancer: Association with tumor invasion, metastasis and heparanase transcription [J].
Zheng, Liduan ;
Pu, Jiarui ;
Jiang, Guosong ;
Weng, Mixia ;
He, June ;
Mei, Hong ;
Hou, Xiaohua ;
Tong, Qiangsong .
PATHOLOGY INTERNATIONAL, 2010, 60 (04) :268-277
[16]  
Zinzindohoué F, 2005, CLIN CANCER RES, V11, P594
12