A novel synthetic material for spinal fusion: a prospective clinical trial of porous bioactive titanium metal for lumbar interbody fusion

被引:73
作者
Fujibayashi, Shunsuke [1 ]
Takemoto, Mitsuru [1 ]
Neo, Masashi [1 ]
Matsushita, Tomiharu [2 ]
Kokubo, Tadashi [2 ]
Doi, Kenji [3 ]
Ito, Tatsuya [4 ]
Shimizu, Akira [4 ]
Nakamura, Takashi [1 ]
机构
[1] Kyoto Univ, Dept Orthoped Surg, Grad Sch Med, Kyoto 6068507, Japan
[2] Chubu Univ, Dept Biomed Sci, Coll Life & Hlth Sci, Kasugai, Aichi 4878501, Japan
[3] Osaka Yakin Kogyou Co Ltd, Miki, Kagawa 6730043, Japan
[4] Kyoto Univ Hosp, Dept Expt Therapeut, Translat Res Ctr, Kyoto 6068507, Japan
基金
日本学术振兴会;
关键词
Porous titanium metal; Spinal fusion; Biomaterial; Clinical trial; TOTAL HIP-ARTHROPLASTY; SODIUM REMOVAL; HEAT-TREATMENT; BONE; RHBMP-2; OSTEOINDUCTION; COMPLICATIONS; CERAMICS; IMPLANTS; LAYER;
D O I
10.1007/s00586-011-1728-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The objective of this study was to establish the efficacy and safety of porous bioactive titanium metal for use in a spinal fusion device, based on a prospective human clinical trial. A high-strength spinal interbody fusion device was manufactured from porous titanium metal. A bioactive surface was produced by simple chemical and thermal treatment. Five patients with unstable lumbar spine disease were treated surgically using this device in a clinical trial approved by our Ethics Review Committee and the University Hospital Medical Information Network. Clinical and radiological results were reported at the minimum follow-up period of 1 year. The optimal mechanical strength and interconnected structure of the porous titanium metal were adjusted for the device. The whole surface of porous titanium metal was treated uniformly and its bioactive ability was confirmed before clinical use. Successful bony union was achieved in all cases within 6 months without the need for autologous iliac crest bone grafting. Two specific findings including an anchoring effect and gap filling were evident radiologically. All clinical parameters improved significantly after the operation and no adverse effects were encountered during the follow-up period. Although a larger and longer-term follow-up clinical study is mandatory to reach any firm conclusions, the study results show that this porous bioactive titanium metal is promising material for a spinal fusion device.
引用
收藏
页码:1486 / 1495
页数:10
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