Resting heart rate: A modifiable prognostic indicator of cardiovascular risk and outcomes?

被引：0
作者：
Arnold, J. Malcolm [1 ]
Fitchett, David H. [2 ]
Howlett, Jonathan G. [3 ]
Lonn, Eva M. [4 ]
Tardif, Jean-Claude [5 ]
机构：
[1] Univ Western Ontario, Univ Hosp, London Hlth Sci Ctr, London, ON N6A 5A5, Canada
[2] Univ Toronto, St Michaels Hosp, Toronto, ON M5B 1W8, Canada
[3] Dalhousie Univ, Queen Elizabeth Hlth Sci Ctr 2, Halifax, NS, Canada
[4] McMaster Univ, Hamilton, ON, Canada
[5] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada
来源：
CANADIAN JOURNAL OF CARDIOLOGY | 2008年 / 24卷
关键词：
cardiovascular disease; clinical outcomes; heart failure; heart rate; myocardial ischemia; prognosis;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A growing body of evidence from clinical trials and epidemiological studies has identified elevated resting heart rate as a predictor of clinical events. Proof of direct cause and effect is limited, because current drugs that lower heart rate (eg, beta-blockers) have multiple mechanisms of action. A new class of drug, selective I-f inhibitors, is under investigation as a 'pure' heart rate-reducing medication and will help confirm if there is a causal link between elevated heart rate and cardiovascular outcomes. The present paper reviews the evidence for elevated heart rate as a cardiovascular risk factor and some of the current clinical trials testing this hypothesis.
引用
收藏
页码：3A / 8A
页数：6
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