Metabolic signatures of immune cells in chronic kidney disease

被引：16
作者：
Li, Jie [1 ]
Yang, Yi [1 ]
Wang, Yanan [1 ]
Li, Qing [1 ]
He, Fan [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Nephroi, Wuhan 430030, Peoples R China
来源：
EXPERT REVIEWS IN MOLECULAR MEDICINE | 2022年 / 24卷
基金：
中国国家自然科学基金;
关键词：
Chronic kidney disease; fibrosis; immune cells; immunometabolism; metabolism; KILLER T-CELLS; TUBULAR EPITHELIAL-CELLS; DENDRITIC CELLS; MACROPHAGE ACTIVATION; RENAL FIBROSIS; REGULATORY T; HYPOXIA; INJURY; GLYCOLYSIS; MTOR;
D O I：
10.1017/erm.2022.35
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Immune cells play a key role in maintaining renal dynamic balance and dealing with renal injury. The physiological and pathological functions of immune cells are intricately connected to their metabolic characteristics. However, immunometabolism in chronic kidney disease (CKD) is not fully understood. Pathophysiologically, disruption of kidney immune cells homeostasis causes inflammation and tissue damage via triggering metabolic reprogramming. The diverse metabolic characteristics of immune cells at different stages of CKD are strongly associated with their different pathological effect. In this work, we reviewed the metabolic characteristics of immune cells (macrophages, natural killer cells, T cells, natural killer T cells and B cells) and several non-immune cells, as well as potential treatments targeting immunometabolism in CKD. We attempt to elaborate on the metabolic signatures of immune cells and their intimate correlation with non-immune cells in CKD.
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页数：9
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