Aberrant expression of CKLF-like MARVEL transmembrane member 5 (CMTM5) by promoter methylation in myeloid leukemia

被引：21

作者：

Niu, Jihong ^{[1
,2
]}

Li, Henan ^{[3
]}

Zhang, Yao ^{[1
,2
]}

Li, Jinlan ^{[1
,2
]}

Xie, Min ^{[1
,2
]}

Li, Lingdi ^{[1
,2
]}

Qin, Xiaoying ^{[1
,2
]}

Qin, Yazhen ^{[1
,2
]}

Guo, Xiaohuan ^{[3
]}

Jiang, Qian ^{[1
,2
]}

Liu, Yanrong ^{[1
,2
]}

Chen, Shanshan ^{[1
,2
]}

Huang, Xiaojun ^{[1
,2
]}

Han, Wenling ^{[3
]}

Ruan, Guorui ^{[1
,2
]}

机构：

[1] Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China

[2] Peking Univ, Inst Hematol, Beijing 100044, Peoples R China

[3] Peking Univ, Ctr Human Dis Genom, Dept Immunol, Sch Basic Med Sci, Beijing 100044, Peoples R China

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 06期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Acute myeloid leukemia; Chronic myeloid leukemia; CMTM5; Methylation; Tumor suppressor gene; TUMOR-SUPPRESSOR GENE; CARCINOMA-CELL-LINES; RESIDUAL DISEASE; PHASE-I; CANCER; APOPTOSIS; IDENTIFICATION; MALIGNANCIES; DECITABINE; PATHWAY;

D O I：

10.1016/j.leukres.2010.11.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CMTM5 has been shown to exhibit tumor suppressor activities, however, its role in leukemia is unclear. Herein we firstly reported the expression and function of CMTM5 in myeloid leukemia. CMTM5 was down-regulated, or undetectable, in leukemia cell lines and bone marrow cells from leukemia patients with promoter methylation. Ectopic expression of CMTM5-v1 strongly inhibited the proliferation of K562 and MEG-01 cells. In addition, significant negative correlations were observed between CMTM5 and three leukemia-specific fusion genes (AML1-ETO, PML-RAR alpha and BCR/ABL1). CMTM5 expression was up-regulated in patients who had undergone treatment. Therefore, CMTM5 may be involved in the pathomechanism of myeloid leukemias. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：771 / 776

页数：6

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