Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities

被引：32
作者：
Du, Lin [1 ]
Li, Dehai [1 ]
Zhang, Guojian [1 ]
Zhu, Tianjiao [1 ]
Ai, Jing [2 ]
Gu, Qianqun [1 ]
机构：
[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON | 2010年 / 66卷 / 47期
关键词：
Penicillium citrinum; Citrinin; Polyketide; Cytotoxicity; Cell cycle arrest; APOPTOSIS; ASSAY;
D O I：
10.1016/j.tet.2010.09.036
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three novel carbon-bridged citrinin dimers dicitrinones A-C (1-3) were Isolated from a volcano ash-derived fungus Penicillium citrinum Their structures were elucidated by spectroscopic methods Dicitrinone A (1) and B (2) are two atropisomeric mixtures which were verified by both NMR and quantum chemical calculations Their cytotoxicity against four tumor cell lines (HL-60 MOLT-4 A-549 and BEL-7402) was evaluated by SRB and mu methods Dicitrinone B (2) arrested the HL-60 cell cycle at the G2/M phase which was analyzed using flow cytometry (C) 2010 Elsevier Ltd All rights reserved
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收藏
页码：9286 / 9290
页数：5
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