Residual Dipolar Couplings as a Powerful Tool for Constitutional Analysis: The Unexpected Formation of Tricyclic Compounds

被引：70

作者：

Kummerloewe, Grit ^{[1
]}

Crone, Benedikt ^{[1
]}

Kretschmer, Manuel ^{[1
]}

Kirsch, Stefan F. ^{[1
]}

Luy, Burkhard ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 11期

关键词：

electrophiles; enynes; NMR spectroscopy; residual dipolar couplings; structure elucidation; INTRAMOLECULAR SCHMIDT REACTIONS; RELATIVE CONFIGURATION; ORGANIC-MOLECULES; NMR; ASSIGNMENT; ALIGNMENT; AZIDES; RDCS; CONFORMATION; CYCLIZATION;

D O I：

10.1002/anie.201007305

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Analyze this! Residual dipolar couplings (RDCs) can be used to determine the constitution of a small molecule when traditional methods for structure elucidation fail. In a case study, a highly congested, tricyclic compound resulting from the electrophilic cyclization of an azide-containing 1,5-enyne was investigated. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2643 / 2645

页数：3

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