In vitro Therapeutic Effects of Folate Receptor-Targeted Delivery of Anti-Atherogenic Nanodrug on Macrophage Foam Cells

被引：4

作者：

Song, Yeong Jun ^{[1
]}

Jung, Sung Yun ^{[1
]}

Park, Kyeongsoon ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Syst Biotechnol, Anseong 17546, Gyeonggi, South Korea

来源：

MACROMOLECULAR RESEARCH | 2022年 / 30卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

macrophage foam cells; folate receptor; nanodrug; lobeglitazone; lipid droplet; ATHEROSCLEROSIS; CANCER;

D O I：

10.1007/s13233-022-0082-0

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Folate receptors (FRs) are overexpressed on activated macrophages in inflammatory diseases. In this regard, the FRs-targeting strategy is a good option for the diagnosis and treatment of macrophage-mediated diseases. Here, we developed FRs-targeted nanomaterials that specifically deliver the anti-atherogenic drug lobeglitazone into macrophage foam cells via a strong binding affinity to FRs. The prepared FRs-targetable nanodrug is nontoxic to macrophage foam cells and efficiently delivers lobeglitazone into macrophage foam cells via the FRs-mediated endocytosis. Consequently, the FRs-targetable nanodrug significantly decreases the formation of foam cells by inhibiting the accumulation of lipid droplets in macrophage foam cells.

引用

页码：703 / 706

页数：4

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