Role of autoantibodies in infertility, miscarriage, and assisted reproductive technology outcomes

被引：4
作者：
Shen, Hui-Hui [1 ,2 ]
Lai, Zhen-Zhen [1 ]
Yang, Hui-Li [1 ]
Shi, Jia-Wei [1 ]
Li, Ming-Qing [1 ,2 ]
机构：
[1] Fudan Univ, Hosp Obstet & Gynecol, Inst Obstet & Gynecol, Lab Reprod Immunol, Shanghai 200080, Peoples R China
[2] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Key Lab Female Reprod Endocrine Related, Shanghai 200011, Peoples R China
来源：
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE | 2021年 / 5卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Antiphospholipid Antibody; In Vitro Fertilization; Oocyte; Sperm; Zona Pellucida; IN-VITRO FERTILIZATION; SERUM ANTIENDOMETRIAL ANTIBODIES; SPERM-IMMOBILIZING ANTIBODIES; FOLLICLE-STIMULATING-HORMONE; THYROID PEROXIDASE ANTIBODY; RECURRENT PREGNANCY LOSS; ANTIPHOSPHOLIPID ANTIBODIES; ANTISPERM ANTIBODIES; SUBCLINICAL HYPOTHYROIDISM; ZONA-PELLUCIDA;
D O I：
10.4103/2096-2924.322829
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Although considerable advances have been made in the field of assisted reproductive technology (ART), millions of couples still suffer from infertility and miscarriage. In a large number of cases, the etiology of these common reproductive failures remains unknown. However, the significance of autoantibodies in infertility and miscarriage has sparked extensive interest because of their pleiotropic roles in disrupting normal pregnancy. This review discusses the pleiotropic roles of a series of autoantibodies in infertility and miscarriage. A brief recapitulation of how the autoantibodies interfere with ART outcomes and treatments for this type of idiopathic infertility or miscarriage is also provided. While several disputes remain to be resolved, further studies employing better designs and larger sample sizes are required in view of the therapeutic potential of autoantibody inhibitors and the future of contraceptive vaccines.
引用
收藏
页码：161 / 173
页数：13
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