A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase

被引：47
作者：
Hong, H
Spencer, JB
Porter, JL
Leadlay, PF
Stinear, T
机构：
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[3] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia
来源：
CHEMBIOCHEM | 2005年 / 6卷 / 04期
关键词：
biosynthesis; buruli ulcer; Mycobacterium; mycolactone; polyketides;
D O I：
10.1002/cbic.200400339
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain of Mycobacterium ulcerans. They possess an extra methyl group at C2′ (shown in red) compared to mycolactone A as a result of the recruitment of a single catalytic domain of altered specificity in the mycolactone polyketide synthase. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：643 / 648
页数：6
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