Noxa Role in Cancer Pathogenesis and Treatment

被引：48

作者：

Morsi, Rami Z. ^{[1
]}

Hage-Sleiman, Rouba ^{[2
]}

Kobeissy, Hadile ^{[4
]}

Dbaibo, Ghassan ^{[3
,4
,5
]}

机构：

[1] Amer Univ Beirut, Fac Med, POB 11-0236, Beirut, Lebanon

[2] Lebanese Univ, Dept Biol, Fac Sci, Hadath, Lebanon

[3] Amer Univ Beirut, Div Pediat Infect Dis, Dept Pediat & Adolescent Med, Fac Med, POB 11-0236, Beirut, Lebanon

[4] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, POB 11-0236, Beirut, Lebanon

[5] Amer Univ Beirut, Ctr Infect Dis Res, Beirut, Lebanon

来源：

CURRENT CANCER DRUG TARGETS | 2018年 / 18卷 / 10期

关键词：

Bcl-2; apoptosis; Noxa; cancer; B-cell lymphoma 2; p53; SMALL-MOLECULE INHIBITOR; CHRONIC LYMPHOCYTIC-LEUKEMIA; CISPLATIN-INDUCED APOPTOSIS; BCL-2 FAMILY PROTEINS; CELL LUNG-CANCER; HISTONE DEACETYLASE INHIBITORS; OBATOCLAX MESYLATE GX15-070; ACUTE MYELOID-LEUKEMIA; BH3 MIMETIC ABT-737; BH3-ONLY PROTEINS;

D O I：

10.2174/1568009618666180308105048

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The B-cell lymphoma 2 (Bcl-2) family proteins play an important role in regulating apoptosis, or programmed cell death, in response to several extracellular and intracellular signals. These proteins are either pro-apoptotic or anti-apoptotic. The pro-apoptotic Noxa is a Bcl-2 family protein that belongs to a subclass of BH3-only proteins. Noxa induces apoptosis via p53-dependent and/or p53-independent mechanisms. While Noxa may play a limited role in apoptosis, it is a crucial player that interacts with several proteins in the apoptosis pathway, highlighting its importance in the pathogenesis and treatment of certain cancers. In this review, we will elucidate the mechanisms by which Noxa regulates apoptosis and review the roles of chemotherapeutic drugs in relation to Noxa.

引用

页码：914 / 928

页数：15

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