Biological functions of microRNAs: a review

被引：565

作者：

Huang, Yong ^{[1
,3
]}

Shen, Xing Jia ^{[1
,3
]}

Zou, Quan ^{[2
]}

Wang, Sheng Peng ^{[1
,3
]}

Tang, Shun Ming ^{[1
,3
]}

Zhang, Guo Zheng ^{[1
,3
]}

机构：

[1] Jiang Su Univ Sci & Technol, Zhenjiang City 212018, Jiangsu Prov, Peoples R China

[2] Xiamen Univ, Sch Informat Sci & Technol, Xiamen 361005, Fujian Prov, Peoples R China

[3] Chinese Acad Agr Sci, Key Lab Silkworm & Mulberry Genet Improvement, Minist Agr, Sericultural Res Inst, Zhenjiang City 212018, Jiangsu Prov, Peoples R China

来源：

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY | 2011年 / 67卷 / 01期

关键词：

MicroRNA; Biogenesis; Function; Expression; Disease; GENE-EXPRESSION; CELL-DIFFERENTIATION; NEURONAL DIFFERENTIATION; CAENORHABDITIS-ELEGANS; INFLAMMATORY RESPONSE; VASCULAR INTEGRITY; MESSENGER-RNAS; CANCER CELLS; STEM-CELLS; C-ELEGANS;

D O I：

10.1007/s13105-010-0050-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a recently discovered family of endogenous, noncoding RNA molecules approximately 22 nt in length. miRNAs modulate gene expression post-transcriptionally by binding to complementary sequences in the coding or 3' untranslated region of target messenger RNAs (mRNAs). It is now clear that the biogenesis and function of miRNAs are related to the molecular mechanisms of various clinical diseases, and that they can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death, viral infection and tumorgenesis. Here, we review recent advances in miRNA research, and discuss the diverse roles of miRNAs in disease.

引用

页码：129 / 139

页数：11

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