The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells

被引：14

作者：

Chuang, Yu-Min ^{[1
]}

Agunbiade, Tolulope A. ^{[2
]}

Tang, Xu-Dong ^{[3
]}

Freudzon, Marianna ^{[4
]}

Almeras, Lionel ^{[5
,6
]}

Fikrig, Erol ^{[1
]}

机构：

[1] Yale Univ, Dept Internal Med, Sect Infect Dis, Sch Med, New Haven, CT 06520 USA

[2] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA

[3] Jiangsu Univ Sci & Technol, Sch Biotechnol, Jiangsu Key Lab Sericultural Biol & Biotechnol, Zhenjiang, Jiangsu, Peoples R China

[4] Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06510 USA

[5] Inst Rech Biomed Armees, Dept Microbiol & Malad Infect, Unite Parasitol & Entomol, Marseille, France

[6] Aix Marseille Univ, AP HM, UMR Vecteurs Infect Trop & Mediterraneennes, SSA,IHU Mediterranee Infect,IRD, Marseille, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 03期

基金：

美国国家卫生研究院;

关键词：

mosquito; saliva protein; sporozoite; gliding; cell traversal; RTS; S/AS01 MALARIA VACCINE; PLASMODIUM SPOROZOITES; GLAND PROTEINS; TRANSMISSION; INFECTION; MAXADILAN; INJECTION; ANOPHELIN; MIGRATION; MOTILITY;

D O I：

10.1093/infdis/jiaa759

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria begins when Plasmodium-infected Anopheles mosquitoes take a blood meal on a vertebrate. During the initial probing process, mosquitoes inject saliva and sporozoites into the host skin. Components of mosquito saliva have the potential to influence sporozoite functionality. Sporozoite-associated mosquito saliva protein 1 (SAMSP1; AGAP013726) was among several proteins identified when sporozoites were isolated from saliva, suggesting it may have an effect on Plasmodium. Recombinant SAMSP1 enhanced sporozoite gliding and cell traversal activity in vitro. Moreover, SAMSP1 decreased neutrophil chemotaxis in vivo and in vitro, thereby also exerting an influence on the host environment in which the sporozoites reside. Active or passive immunization of mice with SAMSP1 or SAMSP1 antiserum diminished the initial Plasmodium burden after infection. Passive immunization of mice with SAMSP1 antiserum also added to the protective effect of a circumsporozoite protein monoclonal antibody. SAMSP1 is, therefore, a mosquito saliva protein that can influence sporozoite infectivity in the vertebrate host.

引用

页码：544 / 553

页数：10

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