Differentiation between Single- and Double-Stranded DNA through Local Capacitance Measurements

被引：5
|
作者：
Estrada-Vargas, Arturo [1 ]
Jambrec, Daliborka [1 ]
Kayran, Yasin Ugur [1 ]
Kuznetsov, Volodymyr [1 ]
Schuhmann, Wolfgang [1 ]
机构：
[1] Ruhr Univ Bochum, Analyt Chem Ctr Electrochem Sci CES, Univ Str 150, D-44780 Bochum, Germany
来源：
CHEMELECTROCHEM | 2016年 / 3卷 / 06期
关键词：
AC-SECM; DNA hybridization; influence diagram; local capacitance; SEIM; SCANNING ELECTROCHEMICAL MICROSCOPY; AC-SECM; IMPEDANCE SPECTROSCOPY; LABEL-FREE; HYBRIDIZATION; SURFACE; VISUALIZATION; MICROARRAYS; OXIDATION; SCIENCE;
D O I：
10.1002/celc.201600075
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Local differentiation of single-stranded (ss) and double-stranded (ds) DNA in microarrays by using electrochemical techniques has gained increasing interest. We propose a method for distinguishing areas on gold electrodes modified with ssDNA and dsDNA based on the difference in their local capacitance. The local capacitance is visualized by means of scanning electrochemical impedance microscopy and alternating-current scanning electrochemical microscopy.
引用
收藏
页码：855 / 857
页数：3
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